Effects of cocaine and levamisole (as adulterant) on the isolated perfused Langendorff heart.
Cardiac flow
Cardiac function
Cocaine
Heart rate
Langendorff-heart
Left ventricular pressure
Levamisole
Journal
International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
01
10
2019
accepted:
14
04
2020
pubmed:
8
5
2020
medline:
10
6
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Cocaine-related deaths occur regularly in forensic routine work. In cases in which the detected concentration of cocaine is rather low and other causes of death apart from intoxication can be ruled out, the question arises if adulterants of cocaine might have played a crucial role. In the present study, cardiac effects of cocaine, of the adulterant levamisole and of mixtures of both were evaluated using the isolated perfused Langendorff heart. While exposed to the substances, functional parameters heart rate, left ventricular pressure and coronary flow were documented. Relevant alterations of these parameters were found for cocaine as well as for levamisole. Exposing the hearts to a mixture of both resulted in a combination of these effects; the emergence of new alterations or an obvious aggravation were not detected. Nevertheless, the results imply that the consumption of cocaine adulterated with levamisole bares an increased risk for cardiac complications, especially in the presence of preexisting cardiac pathologies.
Identifiants
pubmed: 32377925
doi: 10.1007/s00414-020-02300-5
pii: 10.1007/s00414-020-02300-5
pmc: PMC7417403
doi:
Substances chimiques
Levamisole
2880D3468G
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1741-1752Références
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