Failure of Liposomal-amphotericin B Treatment for New World Cutaneous Leishmaniasis due to Leishmania braziliensis.
Leishmania braziliensis
cutaneous leishmaniasis
liposomal-amphotericin B
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
31
7
2020
Statut:
ppublish
Résumé
Liposomal-amphotericin B (L-AmB) is used for cutaneous leishmaniasis (CL); however, its treatment failure has not yet been described in detail. A 58-year-old man returned from the Republic of Venezuela with a cutaneous ulcer on his left lower leg. The causative pathogen was Leishmania braziliensis. We started L-AmB 3 mg/kg/day for 6 days; however, the ulcer did not resolve. The patient was successfully retreated with a higher dose L-AmB 4 mg/kg/day 9 times (total, 36 mg/kg). If L-AmB fails to treat CL and other therapeutics cannot be used, increasing the L-AmB dose is a viable option.
Identifiants
pubmed: 32378656
doi: 10.2169/internalmedicine.4096-19
pmc: PMC7270753
doi:
Substances chimiques
Antiprotozoal Agents
0
liposomal amphotericin B
0
Amphotericin B
7XU7A7DROE
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1227-1230Références
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