Quantitative analysis of hyperkinetic seizures and correlation with seizure onset zone.


Journal

Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R

Informations de publication

Date de publication:
05 2020
Historique:
received: 04 02 2020
revised: 11 03 2020
accepted: 31 03 2020
pubmed: 8 5 2020
medline: 1 12 2020
entrez: 8 5 2020
Statut: ppublish

Résumé

Hyperkinetic epileptic seizures (HKS) are difficult to characterize and localize according to semiologic features. We propose a multicriteria scale to help visual analysis and report results of cerebral localization. We assessed seizures from 37 patients with HKS, explored with stereoelectroencephalography during presurgical evaluation. We used a multicriteria scale (hyperkinetic seizure scale [HSS]) with 10 semiologic features, scored independently by two neurologists. The item scores were used to group seizures using the k-means method. Semiologic features were correlated with the seizure onset zone (SOZ) localization (temporal, prefrontal dorsolateral, prefrontal ventromesial, parietal, insular). Fifty-five seizures were analyzed, and each item of the HSS was compared between the two examiners with good interrater agreement (85.3%). Dystonia, integrated behavior, and bilateral or unilateral hyperkinetic movements were statistically significant according to localization. Three clusters were identified according to the HSS and correlated with different patterns of anatomic localization of SOZ. Cluster 1 was characterized clinically by asymmetric hyperkinetic movements associated with marked dystonia and vocalization. It mainly included parietal seizures. Cluster 2 was characterized by bilateral and symmetrical stereotyped hyperkinetic movements without dystonia. It represented half of temporal seizures and one-third of prefrontal seizures (dorsolateral). Cluster 3 was characterized by seizures with strong emotionality and vocalization with bilateral and symmetrical hyperkinetic movements and integrated behavior. It involved half of temporal seizures and a majority of prefrontal (ventromesial) seizures. We propose a first attempt to quantify clinical patterns of HKS. The HSS may help to predict SOZ localization according to three main groups of hyperkinetic seizures.

Identifiants

pubmed: 32378738
doi: 10.1111/epi.16510
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1019-1026

Informations de copyright

© 2020 International League Against Epilepsy.

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Auteurs

Julie Fayerstein (J)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Aileen McGonigal (A)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Francesca Pizzo (F)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Francesca Bonini (F)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Stanislas Lagarde (S)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Aurore Braquet (A)

Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Agnès Trébuchon (A)

Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Romain Carron (R)

Functional and Stereotactic Neurosurgery Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Didier Scavarda (D)

Pediatric Neurosurgery Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Scholly Julia (S)

Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Isabelle Lambert (I)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Bernard Giusiano (B)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

Fabrice Bartolomei (F)

National Institute of Health and Medical Research, Institute of Systems Neuroscience, Aix Marseille University, Marseille, France.
Epileptology Department, Timone Hospital, Public Assistance Hospitals of Marseille, Marseille, France.

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