Web-Based Intervention Effects on Mild Cognitive Impairment Based on Apolipoprotein E Genotype: Quasi-Experimental Study.
APOE ε4
Alzheimer disease
computerized training
exergaming
mild cognitive impairment
Journal
Journal of medical Internet research
ISSN: 1438-8871
Titre abrégé: J Med Internet Res
Pays: Canada
ID NLM: 100959882
Informations de publication
Date de publication:
07 05 2020
07 05 2020
Historique:
received:
17
07
2019
accepted:
15
12
2019
revised:
19
10
2019
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE ε4 carriers have never been studied before. The effects of different web-based interventions and the APOE isoform-specific differences in training outcomes are investigated. Using a quasi-experimental study design, 202 participants with MCI aged 60 years and older took part in three different intervention programs (physical and cognitive [Long-Lasting Memories, or LLM], cognitive [Active Control, or AC], or physical intervention [Physical Training Control, or PTC]) via an innovative information and communication technologies exergaming platform. Participants in each interventional group were subdivided into APOE ε4 carriers and non-APOE ε4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging. All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score-LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores-AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score-LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE ε4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE ε4+ cognitive AC training group. None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI ΑPOE ε4+ subgroup.
Sections du résumé
BACKGROUND
Apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE ε4 carriers have never been studied before.
OBJECTIVE
The effects of different web-based interventions and the APOE isoform-specific differences in training outcomes are investigated.
METHODS
Using a quasi-experimental study design, 202 participants with MCI aged 60 years and older took part in three different intervention programs (physical and cognitive [Long-Lasting Memories, or LLM], cognitive [Active Control, or AC], or physical intervention [Physical Training Control, or PTC]) via an innovative information and communication technologies exergaming platform. Participants in each interventional group were subdivided into APOE ε4 carriers and non-APOE ε4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging.
RESULTS
All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score-LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores-AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score-LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE ε4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE ε4+ cognitive AC training group.
CONCLUSIONS
None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI ΑPOE ε4+ subgroup.
Identifiants
pubmed: 32379048
pii: v22i5e14617
doi: 10.2196/14617
pmc: PMC7243129
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14617Informations de copyright
©Anthoula C Tsolaki, Magda Tsolaki, Niki Pandria, Eftychia Lazarou, Olymbia Gkatzima, Vasiliki Zilidou, Maria Karagianni, Zafiroula Iakovidou-Kritsi, Vasilios K Kimiskidis, Panagiotis D Bamidis. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 07.05.2020.
Références
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Neurodegener Dis. 2018;18(4):216-224
pubmed: 30205398
Arch Clin Neuropsychol. 2006 Aug;21(5):413-20
pubmed: 16843636
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Arch Neurol. 2012 May;69(5):636-43
pubmed: 22232206
Arch Clin Neuropsychol. 2007 Aug;22(6):739-52
pubmed: 17640848
J Neurol Sci. 2013 May 15;328(1-2):19-23
pubmed: 23499426
Am J Alzheimers Dis Other Demen. 2012 Aug;27(5):315-20
pubmed: 22815080
Hum Psychopharmacol. 2006 Jul;21(5):305-11
pubmed: 16856217
Neuron. 2009 Aug 13;63(3):287-303
pubmed: 19679070
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Ann Clin Transl Neurol. 2016 Aug 26;3(9):668-77
pubmed: 27648456
Aging (Milano). 1999 Dec;11(6):367-72
pubmed: 10738851
Percept Mot Skills. 2007 Jun;104(3 Pt 1):958-60
pubmed: 17688151
Afr Health Sci. 2016 Dec;16(4):1045-1055
pubmed: 28479898
Front Behav Neurosci. 2017 Mar 16;11:47
pubmed: 28360847
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Sci Rep. 2017 Jan 03;7:39471
pubmed: 28045051
Gerontologist. 1969 Autumn;9(3):179-86
pubmed: 5349366
Neurodegener Dis. 2011;8(3):138-45
pubmed: 21135531
Front Aging Neurosci. 2018 Feb 02;10:23
pubmed: 29456502
Arch Clin Neuropsychol. 2013 Feb;28(1):52-64
pubmed: 23179043
J Am Med Inform Assoc. 2006 Jan-Feb;13(1):16-23
pubmed: 16221933
IEEE J Biomed Health Inform. 2017 May;21(3):859-866
pubmed: 28113566
Front Hum Neurosci. 2017 May 16;11:262
pubmed: 28559806
Dialogues Clin Neurosci. 2013 Mar;15(1):99-108
pubmed: 23576893
Neuropsychol Rev. 2017 Dec;27(4):328-353
pubmed: 29019061
Multivariate Behav Res. 2014 Jan 1;49(1):78-91
pubmed: 24860197
Am J Alzheimers Dis Other Demen. 2019 May;34(3):176-187
pubmed: 30518237
Neuropsychol Rev. 2017 Dec;27(4):440-484
pubmed: 29282641
Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2505-9
pubmed: 22254850
Front Aging Neurosci. 2015 Aug 07;7:152
pubmed: 26300772
BMJ. 2009 Jun 29;338:b2393
pubmed: 19564179
Front Aging Neurosci. 2018 Nov 13;10:364
pubmed: 30524264
Neurobiol Aging. 2013 Apr;34(4):1007-17
pubmed: 23159550
Cortex. 2018 Jul;104:103-123
pubmed: 29800787
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Neuroepidemiology. 2010;34(1):43-9
pubmed: 19907191
Curr Behav Neurosci Rep. 2016 Dec;3(4):350-359
pubmed: 28503402
Springerplus. 2013 May 14;2(1):222
pubmed: 23853744
IEEE J Biomed Health Inform. 2016 Jan;20(1):189-200
pubmed: 26731797
Psychol Rep. 2006 Aug;99(1):93-6
pubmed: 17037454
J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):40-9
pubmed: 25720862
Neural Plast. 2018 Dec 2;2018:7301530
pubmed: 30766600
Neurosci Biobehav Rev. 2014 Jul;44:206-20
pubmed: 24705268
PLoS One. 2012;7(7):e40588
pubmed: 22792378
J Aging Phys Act. 2017 Jan;25(1):73-83
pubmed: 27337738
Neurodegener Dis. 2012;10(1-4):216-9
pubmed: 22310934
Front Aging Neurosci. 2018 May 04;10:76
pubmed: 29780318
J Alzheimers Dis. 2018;61(1):333-345
pubmed: 29154279
Am J Geriatr Psychiatry. 2015 Apr;23(4):335-359
pubmed: 24998488
Alzheimers Dement. 2017 Nov;13(11):1197-1206
pubmed: 28501451
J Am Geriatr Soc. 2008 Oct;56(10):1926-31
pubmed: 18811613
Prog Brain Res. 2013;207:403-34
pubmed: 24309264
Aging Ment Health. 2014 Sep;18(7):838-46
pubmed: 24697325