Vaginal and Extra-Vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women Who Have Sex With Men.


Journal

The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675

Informations de publication

Date de publication:
01 04 2022
Historique:
received: 24 01 2020
accepted: 29 04 2020
pubmed: 8 5 2020
medline: 6 4 2022
entrez: 8 5 2020
Statut: ppublish

Résumé

Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB). We used quantitative polymerase chain reaction assays to determine whether presence or concentrations of BVAB in the mouth, anus, vagina, or labia before BV predict risk of incident BV in 72 women who have sex with men. Baseline vaginal and extra-vaginal colonization with Gardnerella spp, Megasphaera spp, Sneathia spp, BVAB-2, Dialister sp type 2, and other BVAB was more common among subjects with incident BV. Prior colonization with BVAB is a consistent risk for BV.

Sections du résumé

BACKGROUND
Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB).
METHODS
We used quantitative polymerase chain reaction assays to determine whether presence or concentrations of BVAB in the mouth, anus, vagina, or labia before BV predict risk of incident BV in 72 women who have sex with men.
RESULTS
Baseline vaginal and extra-vaginal colonization with Gardnerella spp, Megasphaera spp, Sneathia spp, BVAB-2, Dialister sp type 2, and other BVAB was more common among subjects with incident BV.
CONCLUSIONS
Prior colonization with BVAB is a consistent risk for BV.

Identifiants

pubmed: 32379324
pii: 5831787
doi: 10.1093/infdis/jiaa233
pmc: PMC8974833
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1261-1265

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI061628
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

Références

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Auteurs

David N Fredricks (DN)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
University of Washington, Seattle, Washington, USA.

Anna Plantinga (A)

Williams College, Williamstown, Massachusetts, USA.

Sujatha Srinivasan (S)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Antoinette Oot (A)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Andrew Wiser (A)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Tina L Fiedler (TL)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Sean Proll (S)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Michael C Wu (MC)

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Jeanne M Marrazzo (JM)

University of Alabama at Birmingham, Birmingham, Alabama, USA.

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Classifications MeSH