Common gray and white matter abnormalities in schizophrenia and bipolar disorder.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
10
2019
accepted:
22
04
2020
entrez:
8
5
2020
pubmed:
8
5
2020
medline:
4
8
2020
Statut:
epublish
Résumé
This study aimed to investigate abnormalities in the gray matter and white matter (GM and WM, respectively) that are shared between schizophrenia (SZ) and bipolar disorder (BD). We used 3T-magnetic resonance imaging to examine patients with SZ, BD, or healthy control (HC) subjects (aged 20-50 years, N = 65 in each group). We generated modulated GM maps through voxel-based morphometry (VBM) for T1-weighted images and skeletonized fractional anisotropy, mean diffusion, and radial diffusivity maps through tract-based special statistics (TBSS) methods for diffusion tensor imaging (DTI) data. These data were analyzed using a generalized linear model with pairwise comparisons between groups with a family-wise error corrected P < 0.017. The VBM analysis revealed widespread decreases in GM volume in SZ compared to HC, but patients with BD showed GM volume deficits limited to the right thalamus and left insular lobe. The TBSS analysis showed alterations of DTI parameters in widespread WM tracts both in SZ and BD patients compared to HC. The two disorders had WM alterations in the corpus callosum, superior longitudinal fasciculus, internal capsule, external capsule, posterior thalamic radiation, and fornix. However, we observed no differences in GM volume or WM integrity between SZ and BD. The study results suggest that GM volume deficits in the thalamus and insular lobe along with widespread disruptions of WM integrity might be the common neural mechanisms underlying the pathologies of SZ and BD.
Identifiants
pubmed: 32379845
doi: 10.1371/journal.pone.0232826
pii: PONE-D-19-28964
pmc: PMC7205291
doi:
Banques de données
Dryad
['10.5061/dryad.j6q573n9h']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0232826Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
NPJ Schizophr. 2017 Apr 3;3:15
pubmed: 28560261
Mol Psychiatry. 2017 Oct;22(10):1455-1463
pubmed: 27217146
J Affect Disord. 2016 Jan 1;189:290-7
pubmed: 26454335
Trends Neurosci. 2000 Oct;23(10):475-83
pubmed: 11006464
Mol Psychiatry. 2016 Dec;21(12):1710-1716
pubmed: 26857596
Bipolar Disord. 2012 Mar;14(2):135-45
pubmed: 22420589
Schizophr Res. 2017 Jul;185:41-50
pubmed: 28082140
Brain. 1997 Oct;120 ( Pt 10):1823-43
pubmed: 9365373
PLoS One. 2017 Nov 14;12(11):e0188000
pubmed: 29136642
Neuroimage Clin. 2016 Jun 03;12:1-15
pubmed: 27354958
Schizophr Bull. 2012 Sep;38(5):967-80
pubmed: 21415225
Schizophr Res. 2010 Nov;123(2-3):93-104
pubmed: 20832997
Nat Protoc. 2007;2(3):499-503
pubmed: 17406613
Schizophr Res. 2008 Sep;104(1-3):44-60
pubmed: 18703313
JAMA Psychiatry. 2015 Apr;72(4):305-15
pubmed: 25651064
Mol Psychiatry. 2018 Apr;23(4):932-942
pubmed: 28461699
Biol Psychiatry. 2008 Nov 1;64(9):774-81
pubmed: 18486104
Psychol Med. 2015 Mar;45(4):759-70
pubmed: 25089761
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:369-377
pubmed: 30790676
Neurosci Lett. 2011 Feb 4;489(2):94-8
pubmed: 21138758
J Nerv Ment Dis. 1998 Aug;186(8):470-6
pubmed: 9717864
Mol Psychiatry. 2016 Apr;21(4):585
pubmed: 26283641
Transl Psychiatry. 2018 Jan 31;8(1):30
pubmed: 29382821
J Am Acad Psychiatry Law. 2014;42(2):173-81
pubmed: 24986344
J Affect Disord. 2014 Dec;169:118-27
pubmed: 25189991
Eur Arch Psychiatry Clin Neurosci. 2011 Aug;261(5):313-22
pubmed: 21188405
Behav Brain Res. 2012 Feb 1;227(1):91-9
pubmed: 22056751
Psychol Med. 2011 Feb;41(2):225-41
pubmed: 20836900
Schizophr Res. 2010 Mar;117(1):1-12
pubmed: 20071149
Schizophr Bull. 2015 Sep;41(5):1133-42
pubmed: 25548384
Schizophr Res. 2015 Jul;165(2-3):212-9
pubmed: 25935815
Sci Rep. 2016 Sep 21;6:33857
pubmed: 27651212
Schizophr Bull. 2013 Sep;39(5):1129-38
pubmed: 23042112
Br J Psychiatry. 2006 Oct;189:346-53
pubmed: 17012658
Front Hum Neurosci. 2010 Oct 26;4:189
pubmed: 21103008
Lancet. 1995 Feb 18;345(8947):456-7
pubmed: 7853978
J Affect Disord. 2013 Sep 5;150(2):192-200
pubmed: 23810479
J Psychiatr Res. 2011 Jul;45(7):980-8
pubmed: 21306734
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Lancet. 2009 Jan 17;373(9659):234-9
pubmed: 19150704
Radiographics. 2006 Oct;26 Suppl 1:S205-23
pubmed: 17050517
Mol Psychiatry. 2018 May;23(5):1261-1269
pubmed: 29038599
Am J Psychiatry. 2013 Aug;170(8):886-98
pubmed: 23771210
Schizophr Res. 2012 Jul;138(2-3):177-82
pubmed: 22445668
Bipolar Disord. 2013 Sep;15(6):680-93
pubmed: 23796123
Am J Psychiatry. 2013 Nov;170(11):1275-84
pubmed: 23771174
J Affect Disord. 2017 Apr 15;213:138-150
pubmed: 28222360
PLoS One. 2014 Mar 24;9(3):e92573
pubmed: 24664210
JAMA Psychiatry. 2014 Nov;71(11):1222-30
pubmed: 25188810
Psychiatry Res. 2011 Nov 30;194(2):149-56
pubmed: 21924872
J Clin Neurol. 2018 Apr;14(2):129-140
pubmed: 29504292
Lancet. 2013 Apr 20;381(9875):1371-1379
pubmed: 23453885
J Affect Disord. 2016 Jan 1;189:176-83
pubmed: 26437232
Psychiatry Res. 2014 Jan 30;221(1):58-62
pubmed: 24300086
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Am J Psychiatry. 1994 Oct;151(10):1430-6
pubmed: 7916539
J Psychiatry Neurosci. 2015 Jan;40(1):58-68
pubmed: 25268788
Acta Psychiatr Scand. 2012 Nov;126(5):363-76
pubmed: 22509998
Biol Psychiatry. 2018 Nov 1;84(9):644-654
pubmed: 29960671
Am J Psychiatry. 2013 Nov;170(11):1285-96
pubmed: 24185241
Schizophr Res. 2011 Apr;127(1-3):46-57
pubmed: 21300524
Schizophr Bull. 2011 Jan;37(1):177-88
pubmed: 19633214
PLoS One. 2017 Jun 28;12(6):e0178089
pubmed: 28658249