Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism.
Allosteric Regulation
/ drug effects
Allosteric Site
Animals
Binding Sites
Calcium
/ metabolism
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Inositol Phosphates
/ metabolism
Methoxyhydroxyphenylglycol
/ analogs & derivatives
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Mutation
Niacinamide
/ analogs & derivatives
Oxazoles
/ chemistry
Phosphorylation
/ drug effects
Piperazines
/ pharmacology
Pyridines
/ chemistry
Rats
Receptor, Metabotropic Glutamate 5
/ agonists
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
19
02
2020
accepted:
29
04
2020
pubmed:
8
5
2020
medline:
15
12
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
Allosteric modulators of metabotropic glutamate receptor subtype 5 (mGlu
Identifiants
pubmed: 32380090
pii: S0006-2952(20)30239-2
doi: 10.1016/j.bcp.2020.114011
pii:
doi:
Substances chimiques
1-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-((4-fluorobenzyl)oxy)ethanone
0
5-((3-fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide
0
Grm5 protein, rat
0
Inositol Phosphates
0
Oxazoles
0
Piperazines
0
Pyridines
0
Receptor, Metabotropic Glutamate 5
0
VU0409551
0
Niacinamide
25X51I8RD4
Methoxyhydroxyphenylglycol
534-82-7
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Calcium
SY7Q814VUP
3,4-dihydroxyphenylglycol
UEH9K539KJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114011Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.