Vagal sensory neurons and gut-brain signaling.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
20
10
2019
revised:
13
03
2020
accepted:
16
03
2020
pubmed:
8
5
2020
medline:
12
9
2020
entrez:
8
5
2020
Statut:
ppublish
Résumé
Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurological, and immunological disorders. Using state-of-the-art technologies including single-cell genomic analysis, real-time neural activity recording, trans-synaptic tracing, and electron microscopy, novel physiological functions of vagal gut afferents have been uncovered, and new gut-to-brain pathways have been revealed. Here, we review the most recent findings on vagal sensory neurons and the gut-brain signaling, focusing on the anatomical basis and the underlying molecular and cellular mechanisms. Such new discoveries explain some of the old puzzling problems and also raise new questions in this exciting and rapidly growing field.
Identifiants
pubmed: 32380360
pii: S0959-4388(20)30063-5
doi: 10.1016/j.conb.2020.03.006
pmc: PMC7560965
mid: NIHMS1580160
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-140Subventions
Organisme : NHLBI NIH HHS
ID : DP2 HL151354
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK113047
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT012041
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150449
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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