Combination of two antithrombogenic methodologies for preventing thrombus formation on a poly(ether ether ketone) substrate.
Antithrombogenicity
coagulation system
graft polymer
platelet adhesion
polymer biomaterials
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
16 Apr 2020
16 Apr 2020
Historique:
received:
18
01
2020
revised:
02
04
2020
accepted:
05
04
2020
pubmed:
8
5
2020
medline:
8
5
2020
entrez:
8
5
2020
Statut:
aheadofprint
Résumé
To enhance the total antithrombogenicity of poly(ether ether ketone) (PEEK), we examined a combination of two methodologies for the suppression of activation in both the platelet and coagulation systems. A random copolymer (PMT) composed of a zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) unit and a cationic 2-methacryloyloxyethyl trimethylammonium chloride (TMAEMA) unit was grafted onto the PEEK surface by photoinduced self-initiated graft polymerization of the PEEK substrate (PMTx-g-PEEK). Then, negatively charged heparin was immobilized by ionic binding with TMAEMA units (Hep/PMTx-g-PEEK). The TMAEMA unit composition on grafted PMT altered the surface ζ-potentials of the PEEK substrates. Amounts of immobilized heparin depended on the ζ-potential. The concentration of heparin became constant on the sample surface where the TMAEMA unit composition was 30% or more, and was approximately 2.0 μg/cm
Identifiants
pubmed: 32380403
pii: S0927-7765(20)30251-4
doi: 10.1016/j.colsurfb.2020.111021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111021Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.