The shared KEGG pathways between icariin-targeted genes and osteoporosis.
JNK
bioinformatics
icariin
osteogenesis
osteoporosis
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
07 05 2020
07 05 2020
Historique:
received:
30
12
2019
accepted:
30
03
2020
pubmed:
8
5
2020
medline:
26
2
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Osteoporosis is a common metabolic bone disease that affects about 40% of postmenopausal women. Treatment options for osteoporosis are limited, however. Icariin is an herbal substance that has been shown to improve bone mass, but the mechanisms are largely unknown. Using bioinformatics analysis, we have identified the hub genes and KEGG pathways shared between icariin-targeted genes and osteoporosis. The top five shared KEGG pathways were the Toll-like receptor signaling pathway, adipocytokine pathway, neurotrophin signaling pathway, NOD-like receptor signaling, and B cell receptor signaling pathway; the hub genes were RELA, NFKBIA, and IKBKB, belonging to the NF-κB family. The identified icariin-targeted genes are involved in inflammation, insulin resistance, apoptosis, and immune responses, and regulate the PI3K-Akt, NF-κB, MAPK, and JNK signaling pathways. Our
Identifiants
pubmed: 32380477
pii: 103133
doi: 10.18632/aging.103133
pmc: PMC7244047
doi:
Substances chimiques
Flavonoids
0
RNA
63231-63-0
icariin
VNM47R2QSQ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8191-8201Références
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