Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
23
01
2020
accepted:
29
04
2020
revised:
17
04
2020
pubmed:
8
5
2020
medline:
24
6
2021
entrez:
8
5
2020
Statut:
ppublish
Résumé
Post-traumatic stress disorder (PTSD) is a debilitating disorder that develops in some people following trauma exposure. Trauma and PTSD have been associated with accelerated cellular aging. This study evaluated the effect of trauma and PTSD on accelerated GrimAge, an epigenetic predictor of lifespan, in traumatized civilians. This study included 218 individuals with current PTSD, 427 trauma-exposed controls without any history of PTSD and 209 subjects with lifetime PTSD history who are not categorized as current PTSD cases. The Traumatic Events Inventory (TEI) and Clinician-Administered PTSD Scale (CAPS) were used to measure lifetime trauma burden and PTSD, respectively. DNA from whole blood was interrogated using the MethylationEPIC or HumanMethylation450 BeadChips. GrimAge estimates were calculated using the methylation age calculator. Cortical thickness of 69 female subjects was assessed by using T1-weighted structural MRI images. Associations between trauma exposure, PTSD, cortical thickness, and GrimAge acceleration were tested with multiple regression models. Lifetime trauma burden (p = 0.03), current PTSD (p = 0.02) and lifetime PTSD (p = 0.005) were associated with GrimAge acceleration, indicative of a shorter predicted lifespan. The association with lifetime PTSD was replicated in an independent cohort (p = 0.04). In the MRI sub sample, GrimAge acceleration also associated with cortical atrophy in the right lateral orbitofrontal cortex (p
Identifiants
pubmed: 32380512
doi: 10.1038/s41386-020-0700-5
pii: 10.1038/s41386-020-0700-5
pmc: PMC7421899
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609-1616Subventions
Organisme : NIMHD NIH HHS
ID : R01 MD011728
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH071537
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD100902
Pays : United States
Organisme : NIMH NIH HHS
ID : RC1 MH088283
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096764
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA022720
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD102974
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108826
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD050924
Pays : United States
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