Effects of Prenatal Exposure to a Low-Dose of Bisphenol A on Sex Differences in Emotional Behavior and Central Alpha
Air Pollutants, Occupational
Animals
Behavior, Animal
Benzhydryl Compounds
/ administration & dosage
Central Nervous System
/ drug effects
Emotions
/ drug effects
Estrogens, Non-Steroidal
/ administration & dosage
Female
Male
Maternal Exposure
/ adverse effects
Mice
Models, Animal
Phenols
/ administration & dosage
Pregnancy
Prenatal Exposure Delayed Effects
Receptors, Adrenergic, alpha-2
/ metabolism
Sex Characteristics
alpha2 adrenergic receptors
bipshenol A
catecholamines
estrogen
ethology
sex differences
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 May 2020
05 May 2020
Historique:
received:
28
02
2020
revised:
27
03
2020
accepted:
30
04
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Prenatal exposure to bisphenol A (BPA) influences the development of sex differences neurologically and behaviorally across many species of vertebrates. These effects are a consequence of BPA's estrogenic activity and its ability to act as an endocrine disrupter even, at very low doses. When exposure to BPA occurs during critical periods of development, it can interfere with the normal activity of sex steroids, impacting the fate of neurons, neural connectivity and the development of brain regions sensitive to steroid activity. Among the most sensitive behavioral targets of BPA action are behaviors that are characterized by a sexual dimorphism, especially emotion and anxiety related behaviors, such as the amount of time spent investigating a novel environment, locomotive activity and arousal. Moreover, in some species of rodents, BPA exposure affected males' sexual behaviors. Interestingly, these behaviors are at least in part modulated by the catecholaminergic system, which has been reported to be a target of BPA action. In the present study we investigated the influence of prenatal exposure of mice to a very low single dose of BPA on emotional and sexual behaviors and on the density and binding characteristics of alpha
Identifiants
pubmed: 32380724
pii: ijms21093269
doi: 10.3390/ijms21093269
pmc: PMC7246441
pii:
doi:
Substances chimiques
Air Pollutants, Occupational
0
Benzhydryl Compounds
0
Estrogens, Non-Steroidal
0
Phenols
0
Receptors, Adrenergic, alpha-2
0
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of University and Research (MIUR)
ID : MM05107834_003
Références
Endocrinology. 2005 Feb;146(2):607-12
pubmed: 15498886
Psychoneuroendocrinology. 1991;16(1-3):25-40
pubmed: 1961842
Curr Opin Behav Sci. 2016 Feb;7:69-75
pubmed: 27019862
Novartis Found Symp. 2000;230:74-85; discussion 85-93
pubmed: 10965503
J Neuroendocrinol. 2014 Oct;26(10):627-40
pubmed: 25059569
Nat Neurosci. 2011 Jun;14(6):677-83
pubmed: 21613996
Front Psychol. 2013 Nov 26;4:863
pubmed: 24324449
J Pharmacol Exp Ther. 1994 Mar;268(3):1362-7
pubmed: 7908054
J Neuroendocrinol. 2004 Mar;16(3):183-90
pubmed: 15049848
Endocrinology. 2006 Jun;147(6 Suppl):S56-69
pubmed: 16690810
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5335-40
pubmed: 9560276
J Neuroendocrinol. 1989 Oct 1;1(5):383-8
pubmed: 19210432
Rev Reprod. 1997 Jan;2(1):1-6
pubmed: 9414459
Endocrine. 2001 Mar;14(2):165-74
pubmed: 11394633
Toxicol Sci. 2014 Aug 1;140(2):374-92
pubmed: 24798382
Hum Reprod. 2002 Nov;17(11):2839-41
pubmed: 12407035
Nat Rev Neurosci. 2009 Mar;10(3):211-23
pubmed: 19190638
J Comp Neurol. 1982 Dec 1;212(2):118-30
pubmed: 7187914
Brain Res. 1988 May 16;468(2):306-10
pubmed: 3382961
Neurosci Lett. 2001 May 18;304(1-2):73-6
pubmed: 11335058
Mol Cell Endocrinol. 2014 Dec;398(1-2):101-13
pubmed: 25304273
Front Neuroendocrinol. 1996 Jan;17(1):51-125
pubmed: 8788569
Psychoneuroendocrinology. 1994;19(5-7):603-10
pubmed: 7938358
Neuropathology. 2014 Dec;34(6):527-34
pubmed: 24985408
J Neurochem. 2001 Aug;78(4):685-93
pubmed: 11520889
Horm Behav. 2013 Apr;63(4):598-605
pubmed: 23470777
Cell Tissue Res. 1997 Apr;288(1):1-10
pubmed: 9042767
Mol Cell Endocrinol. 2018 May 15;467:21-30
pubmed: 29100889
Behav Brain Res. 2011 Jan 1;216(1):193-9
pubmed: 20678529
Endocrinology. 2006 Aug;147(8):3681-91
pubmed: 16675520
Brain Res Brain Res Rev. 2003 Apr;42(1):33-84
pubmed: 12668290
Brain Res. 1995 Mar 13;674(1):26-32
pubmed: 7773692
Physiol Behav. 2001 Jun;73(3):411-20
pubmed: 11438369
Endocrinology. 2014 Feb;155(2):502-12
pubmed: 24265451
J Comp Neurol. 2008 Dec 10;511(5):610-27
pubmed: 18924139
Neurochem Int. 2007 May;50(6):783-90
pubmed: 17403554
Reprod Toxicol. 2007 Aug-Sep;24(2):139-77
pubmed: 17825522
Annu Rev Neurosci. 2002;25:507-36
pubmed: 12052919
Brain Res Bull. 2005 Apr 15;65(3):235-40
pubmed: 15811586
J Neurosci. 2002 Nov 1;22(21):9320-30
pubmed: 12417657
J Neurocytol. 2000 May-Jun;29(5-6):375-85
pubmed: 11424954
Front Neuroendocrinol. 2010 Jul;31(3):341-58
pubmed: 20457175
J Comp Neurol. 1993 Apr 8;330(2):195-220
pubmed: 8491868
Annu Rev Neurosci. 1984;7:413-42
pubmed: 6370082
Horm Behav. 2011 Feb;59(2):246-51
pubmed: 21185296
Biomed Chromatogr. 2004 Oct;18(8):501-7
pubmed: 15386523
Horm Behav. 2007 Sep;52(3):307-16
pubmed: 17568585
Environ Health Perspect. 2002 Nov;110(11):A703-7
pubmed: 12417499
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14077-82
pubmed: 9391155
Brain Res Mol Brain Res. 2002 Aug 15;104(2):220-6
pubmed: 12225877
Annu Rev Physiol. 2005;67:259-84
pubmed: 15709959
Physiol Behav. 1996 Mar;59(3):537-42
pubmed: 8700957
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7538-40
pubmed: 10377450
Horm Behav. 1976 Mar;7(1):105-38
pubmed: 819345
Brain Res Dev Brain Res. 1992 Jun 19;67(2):211-5
pubmed: 1511516
Nature. 1999 Oct 21;401(6755):763-4
pubmed: 10548101
Brain Res. 1988 Mar 1;442(2):205-13
pubmed: 2836018
Endocr Rev. 2018 Aug 1;39(4):424-439
pubmed: 29668873
Environ Health Perspect. 2003 Jul;111(9):1180-7
pubmed: 12842771
Brain Res Mol Brain Res. 1994 Jan;21(1-2):133-49
pubmed: 8164514
Eur J Neurosci. 2008 Feb;27(4):791-800
pubmed: 18333959
Environ Health Perspect. 2002 Jun;110 Suppl 3:415-22
pubmed: 12060838
J Neuroendocrinol. 2008 Oct;20(10):1155-64
pubmed: 18680559
Neurotoxicol Teratol. 2012 May-Jun;34(3):331-7
pubmed: 22507915
Nat Rev Endocrinol. 2019 Jun;15(6):366-374
pubmed: 30842650
Neuroscience. 1996 Sep;74(1):199-218
pubmed: 8843087
J Neurosci. 1993 Aug;13(8):3448-55
pubmed: 8101869
Brain Res. 1978 Jun 16;148(2):333-46
pubmed: 656937
J Neurobiol. 2003 Mar;54(4):638-47
pubmed: 12555275
Brain Res Bull. 2001 Sep 1;56(1):73-8
pubmed: 11604252
Environ Res. 2008 Oct;108(2):150-7
pubmed: 18949834
Neuroscience. 1996 Nov;75(1):187-96
pubmed: 8923533
Environ Health Perspect. 2002 Jun;110 Suppl 3:409-14
pubmed: 12060837
J Endocrinol. 2014 Feb 10;220(3):375-88
pubmed: 24403293
Neurosci Res. 2003 Mar;45(3):345-56
pubmed: 12631470