Challenges in Matrix Metalloproteinases Inhibition.
TIMP
matrix metalloproteinases
synthetic inhibitors
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
05 05 2020
05 05 2020
Historique:
received:
09
04
2020
revised:
27
04
2020
accepted:
30
04
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented.
Identifiants
pubmed: 32380782
pii: biom10050717
doi: 10.3390/biom10050717
pmc: PMC7277161
pii:
doi:
Substances chimiques
Matrix Metalloproteinase Inhibitors
0
Tissue Inhibitor of Metalloproteinases
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : A MOLECULAR VIEW OF DENTAL RESTORATION, PTDC/SAU-BMA/122444/2010
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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