Effects of Radiation on the Tumor Microenvironment.
Journal
Seminars in radiation oncology
ISSN: 1532-9461
Titre abrégé: Semin Radiat Oncol
Pays: United States
ID NLM: 9202882
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
9
9
2021
Statut:
ppublish
Résumé
A malignant tumor consists of malignant cells as well as a wide array of normal host tissues including stroma, vasculature, and immune infiltrate. The interaction between cancer and these host tissues is critical as these host tissues play a variety of roles in supporting or resisting disease progression. Radiotherapy (RT) has direct effects on malignant cells, but, also, critically important effects on these other components of the tumor microenvironment (TME). Given the growing role of immune checkpoint inhibitors and other immunotherapy strategies, understanding how RT affects the TME, particularly the immune compartment, is essential to advance RT in this new era of cancer therapy. The interactions between RT and the TME are complex, affecting the innate and adaptive arms of the immune system. RT can induce both proinflammatory effects and immune suppressive effects that can either promote or impede antitumor immunity. It is likely that the initial proinflammatory effects of RT eventually lead to rebound immune-suppression as chronic inflammation sets in. The exact kinetics and nature of how RT changes the TME likely depends on timing, dose, fractionation, site irradiated, and tumor type. With increased understanding of the effects of RT on the TME, in the future it is likely that we will be able to personalize RT by varying the dose, site, and timing of intervention to generate the desired response to partner with immunotherapy strategies.
Identifiants
pubmed: 32381294
pii: S1053-4296(19)30079-7
doi: 10.1016/j.semradonc.2019.12.004
pmc: PMC8764968
mid: NIHMS1764541
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-157Subventions
Organisme : NCI NIH HHS
ID : K08 CA191139
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA093373
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220000
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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