The Impact of Intracortical Lesions on Volumes of Subcortical Structures in Multiple Sclerosis.
Adult
Atrophy
/ diagnostic imaging
Brain
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Cross-Sectional Studies
Disease Progression
Female
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis
/ diagnostic imaging
Retrospective Studies
Thalamus
/ diagnostic imaging
White Matter
/ diagnostic imaging
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
12
12
2019
accepted:
27
02
2020
pubmed:
10
5
2020
medline:
11
11
2020
entrez:
9
5
2020
Statut:
ppublish
Résumé
Recent studies showed thalamic atrophy in the early stages of MS. We investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in MS. Seventy-one patients with MS were included. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR, respectively, by using 3D Slicer. Volumes of white matter T1 hypointensities and subcortical gray matter, thalamus, caudate, putamen, and pallidum volumes were calculated using FreeSurfer. Age, MS duration, and the Expanded Disability Status Scale score were assessed. Patients with intracortical lesions were older ( Thalamic atrophy was explained better by intracortical lesions than by white matter lesion and T1 hypointensity volumes, especially in patients with more profound disability.
Sections du résumé
BACKGROUND AND PURPOSE
Recent studies showed thalamic atrophy in the early stages of MS. We investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in MS.
MATERIALS AND METHODS
Seventy-one patients with MS were included. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR, respectively, by using 3D Slicer. Volumes of white matter T1 hypointensities and subcortical gray matter, thalamus, caudate, putamen, and pallidum volumes were calculated using FreeSurfer. Age, MS duration, and the Expanded Disability Status Scale score were assessed.
RESULTS
Patients with intracortical lesions were older (
CONCLUSIONS
Thalamic atrophy was explained better by intracortical lesions than by white matter lesion and T1 hypointensity volumes, especially in patients with more profound disability.
Identifiants
pubmed: 32381540
pii: ajnr.A6513
doi: 10.3174/ajnr.A6513
pmc: PMC7228180
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
804-808Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by American Journal of Neuroradiology.
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