Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4

Allografts Animals CD4-Positive T-Lymphocytes / drug effects Cells, Cultured Flow Cytometry Forkhead Transcription Factors / metabolism Graft Rejection Humans Interleukin-2 / pharmacology Interleukin-2 Receptor alpha Subunit / metabolism Mice Sirolimus / pharmacology T-Lymphocytes, Regulatory / drug effects

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
08 2020
Historique:
received: 27 05 2019
accepted: 03 05 2020
pubmed: 10 5 2020
medline: 19 12 2020
entrez: 9 5 2020
Statut: ppublish

Résumé

Islet transplantation is an emerging therapy for type 1 diabetes and hypoglycemic unawareness. However, a key challenge for islet transplantation is cellular rejection and the requirement for long-term immunosuppression. In this study, we established a diabetic humanized NOD-scidIL2Rγ

Identifiants

DOI: 10.2337/db19-0525 PMID: 32381646
pubmed: 32381646
pii: db19-0525
doi: 10.2337/db19-0525
doi:

Substances chimiques

FOXP3 protein, human 0
Forkhead Transcription Factors 0
Interleukin-2 0
Interleukin-2 Receptor alpha Subunit 0
Sirolimus W36ZG6FT64

Banques de données

figshare
['10.2337/figshare.12241664']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1735-1748

Informations de copyright

© 2020 by the American Diabetes Association.

Auteurs

Min Hu (M)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia min.hu@sydney.edu.au philip.oconnell@sydney.edu.au.
Westmead Clinical Schools, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
ORCID: 0000-0003-3750-220X

Wayne J Hawthorne (WJ)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Leigh Nicholson (L)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Heather Burns (H)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Yi Wen Qian (YW)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

David Liuwantara (D)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Elvira Jimenez Vera (E)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Yi Vee Chew (YV)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Lindy Williams (L)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Shounan Yi (S)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Karen Keung (K)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Debbie Watson (D)

Molecular Horizons and School of Chemistry and Molecular Bioscience, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.

Natasha Rogers (N)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.

Stephen I Alexander (SI)

Centre for Kidney Research, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Philip J O'Connell (PJ)

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia min.hu@sydney.edu.au philip.oconnell@sydney.edu.au.
Westmead Clinical Schools, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
ORCID: 0000-0002-2036-283X

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Classifications MeSH

questionsmedicales.fr › Régions du corps › Transplants › Allogreffes › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Eucaryotes › Animaux › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Cellules › Cellules cultivées › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-2 › Sous-unité alpha du récepteur à l'interleukine-2 › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Sirolimus › Low-Dose Interleukin-2 Combined With Rapamycin...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Low-Dose Interleukin-2 Combined With Rapamycin...