Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence.
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
12
2019
revised:
18
03
2020
accepted:
25
03
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
10
5
2020
Statut:
epublish
Résumé
Infections by microbes (viruses, bacteria, and fungi) and parasites can cause serious diseases in both humans and animals. Heavy use of antimicrobials has created selective pressure and caused resistance to currently available antibiotics, hence the need for finding new and better antibiotics. Natural products, especially from plants, are known for their medicinal properties, including antimicrobial and anthelmintic activities. Geoclimatic variation, together with diversity in ethnomedicinal traditions, has made the Himalayas of Nepal an invaluable repository of traditional medicinal plants. We studied antiviral, antibacterial, antifungal, and anthelmintic activities of medicinal plants, selected based upon ethnobotanical evidence. Ethanolic and methanolic extracts were tested (1) on a panel of microbes: two Gram-positive bacteria ( Of 18 plants studied, In countries like Nepal, with a high burden of infectious and parasitic diseases, and a current health system unable to combat the burden of diseases, evaluation of local plants as a treatment or potential source of drugs can help expand treatment options. Screening plants against a broad range of pathogens (bacteria, viruses, fungi, and parasites) will support bioprospecting in Nepal, which may eventually lead to new drug development.
Sections du résumé
BACKGROUND
BACKGROUND
Infections by microbes (viruses, bacteria, and fungi) and parasites can cause serious diseases in both humans and animals. Heavy use of antimicrobials has created selective pressure and caused resistance to currently available antibiotics, hence the need for finding new and better antibiotics. Natural products, especially from plants, are known for their medicinal properties, including antimicrobial and anthelmintic activities. Geoclimatic variation, together with diversity in ethnomedicinal traditions, has made the Himalayas of Nepal an invaluable repository of traditional medicinal plants. We studied antiviral, antibacterial, antifungal, and anthelmintic activities of medicinal plants, selected based upon ethnobotanical evidence.
METHODS
METHODS
Ethanolic and methanolic extracts were tested (1) on a panel of microbes: two Gram-positive bacteria (
RESULTS
RESULTS
Of 18 plants studied,
CONCLUSIONS
CONCLUSIONS
In countries like Nepal, with a high burden of infectious and parasitic diseases, and a current health system unable to combat the burden of diseases, evaluation of local plants as a treatment or potential source of drugs can help expand treatment options. Screening plants against a broad range of pathogens (bacteria, viruses, fungi, and parasites) will support bioprospecting in Nepal, which may eventually lead to new drug development.
Identifiants
pubmed: 32382275
doi: 10.1155/2020/1043471
pmc: PMC7193273
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1043471Informations de copyright
Copyright © 2020 Bishnu Joshi et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Indian J Pharmacol. 2011 Nov;43(6):689-93
pubmed: 22144775
J Ethnopharmacol. 2006 Jul 19;106(3):290-302
pubmed: 16698208
Cancer Biol Ther. 2005 Nov;4(11):1248-54
pubmed: 16258257
Steroids. 2012 Oct;77(12):1242-8
pubmed: 22846376
Molecules. 2016 Mar 14;21(3):293
pubmed: 26985889
J Nat Prod. 2007 Sep;70(9):1434-8
pubmed: 17844996
J Ethnopharmacol. 2014 Jun 11;154(2):268-85
pubmed: 24727551
J Ethnopharmacol. 2015 Nov 4;174:253-60
pubmed: 26297842
J Ethnopharmacol. 2003 Sep;88(1):19-44
pubmed: 12902048
Arch Med Res. 2005 Nov-Dec;36(6):697-705
pubmed: 16216651
J Ethnopharmacol. 2015 Dec 24;176:494-8
pubmed: 26602454
Int J Mol Sci. 2013 May 03;14(5):9618-27
pubmed: 23644889
Fitoterapia. 2006 Jan;77(1):43-6
pubmed: 16253438
Sci Rep. 2016 Aug 30;6:32101
pubmed: 27572696
Mol Aspects Med. 2006 Feb;27(1):1-93
pubmed: 16105678
Front Pharmacol. 2018 Mar 15;9:215
pubmed: 29599720
Parasite. 2018;25:10
pubmed: 29528842
J Funct Foods. 2013 Jul;5(3):1236-1243
pubmed: 23878618
J Nat Prod. 2016 Mar 25;79(3):629-61
pubmed: 26852623
BMC Complement Altern Med. 2014 Sep 20;14:342
pubmed: 25238673
Asian Pac J Trop Biomed. 2013 Mar;3(3):244-52
pubmed: 23620847
Parasitology. 2013 Jul;140(8):952-8
pubmed: 23552446
J Ethnopharmacol. 2016 Apr 22;182:200-20
pubmed: 26844923
J Ethnopharmacol. 2010 Mar 2;128(1):166-71
pubmed: 20064591
BMC Res Notes. 2012 Mar 20;5:158
pubmed: 22433844
PLoS One. 2015 Sep 25;10(9):e0139338
pubmed: 26405764
Phytochemistry. 2006 Sep;67(18):2071-7
pubmed: 16930642
Int J Antimicrob Agents. 2018 Nov;52(5):622-628
pubmed: 30063998
Curr Opin Chem Biol. 2007 Oct;11(5):480-4
pubmed: 17884696
Nat Prod Res. 2007 Apr;21(4):321-7
pubmed: 17479420
J Nat Prod. 2007 Mar;70(3):461-77
pubmed: 17309302
Asian Pac J Trop Biomed. 2013 Feb;3(2):100-4
pubmed: 23593587
J Ethnobiol Ethnomed. 2008 Dec 02;4:24
pubmed: 19055723
J Ethnopharmacol. 1995 Aug 11;48(1):1-6
pubmed: 8569241
J Ethnopharmacol. 2000 Sep;72(1-2):1-20
pubmed: 10967448
J Tradit Complement Med. 2017 May 11;8(1):24-38
pubmed: 29321986
FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):295-300
pubmed: 15681161
J Ethnopharmacol. 2000 Nov;73(1-2):175-83
pubmed: 11025154
Planta Med. 1993 Aug;59(4):384-6
pubmed: 17235996
J Ethnopharmacol. 2015 May 13;165:103-17
pubmed: 25571849
J Ethnopharmacol. 2014;151(1):158-75
pubmed: 24177353
J Nat Prod. 2008 Jan;71(1):130-3
pubmed: 18177007
Anc Sci Life. 2000 Jul;20(1-2):14-8
pubmed: 22556992
Phytother Res. 2006 Jul;20(7):607-9
pubmed: 16619334
Front Pharmacol. 2017 Oct 23;8:658
pubmed: 29109684
Nat Prod Res. 2016 Jul;30(13):1459-63
pubmed: 26158392
Asian Pac J Trop Med. 2012 Jul;5(7):518-22
pubmed: 22647812
Drug Discov Today. 2009 Aug;14(15-16):804-11
pubmed: 19477288
J Ethnopharmacol. 2018 Oct 28;225:220-233
pubmed: 30005956
Evid Based Complement Alternat Med. 2018 May 6;2018:4394687
pubmed: 29853952
Nature. 2016 Jan 21;529(7586):336-43
pubmed: 26791724
Bioorg Med Chem Lett. 2008 Oct 15;18(20):5614-7
pubmed: 18793855
J Intercult Ethnopharmacol. 2016 Aug 14;5(4):383-389
pubmed: 27757268
Phytochemistry. 2016 Jan;121:20-9
pubmed: 26546502
World J Gastroenterol. 2006 Nov 28;12(44):7136-42
pubmed: 17131475
Anc Sci Life. 2009 Jul;29(1):17-9
pubmed: 22557338
Phytomedicine. 2010 Dec 1;17(14):1102-5
pubmed: 20576414
J Ethnopharmacol. 2016 Nov 4;192:292-301
pubmed: 27469196
Toxicol Ind Health. 2016 Jul;32(7):1254-9
pubmed: 25501256
Planta Med. 1988 Apr;54(2):120-2
pubmed: 2900531
Front Pharmacol. 2019 Sep 03;10:955
pubmed: 31551771