High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma.
hepatocellular carcinoma
long non-coding RNA SNHG7
overall survival
progression-free survival
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
17
10
2019
accepted:
13
12
2019
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
10
5
2020
Statut:
ppublish
Résumé
Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportional models were used to study the impact on clinical outcome. Expression of lncRNA-SNHG7 was much higher in cancer tissues than that in para-cancer tissues. The lncRNA-SNHG7 expression was correlated with tumor number, lymph node metastasis and clinical stage (P<0.05). In addition, HCC patients with higher lncRNA-SNHG7 expression had significantly poorer progression-free survival time and overall survival time (P<0.001). Both univariate analysis and multivariate analysis indicated that high expression of lncRNA-SNHG7 was an independent predictor of poor prognosis in HCC. LncRNA-SNHG7 might contribute to the development of HCC and serve as a clinical biomarker and a therapeutic target for HCC patients.
Identifiants
pubmed: 32382340
doi: 10.3892/ol.2020.11490
pii: OL-0-0-11490
pmc: PMC7202315
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3959-3963Informations de copyright
Copyright: © Shen et al.
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