Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression.
Wnt/β‐catenin/Snail pathway
breast cancer
cancer metabolism
pyruvate carboxylase
small molecule ZY‐444
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
04
12
2019
revised:
14
02
2020
accepted:
24
02
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
10
5
2020
Statut:
epublish
Résumé
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis-associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY-444 ((
Identifiants
pubmed: 32382484
doi: 10.1002/advs.201903483
pii: ADVS1663
pmc: PMC7201266
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1903483Informations de copyright
© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Biochem Mol Toxicol. 2015 Apr;29(4):157-64
pubmed: 25487712
EMBO J. 2014 Jul 1;33(13):1454-73
pubmed: 24825347
Cell Death Dis. 2013 Mar 07;4:e532
pubmed: 23470539
J Natl Cancer Inst. 2013 Jan 2;105(1):47-58
pubmed: 23178439
Cancer Cell. 2011 Nov 15;20(5):674-88
pubmed: 22094260
J Biol Chem. 2002 Aug 23;277(34):30409-12
pubmed: 12087111
Nat Cell Biol. 2015 Oct;17(10):1317-26
pubmed: 26302408
Cancer Res. 2012 Jul 15;72(14):3607-17
pubmed: 22637725
Diabetologia. 2008 Nov;51(11):2022-30
pubmed: 18769905
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):537-551
pubmed: 27890529
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Clin Cancer Res. 2010 Oct 1;16(19):4695-701
pubmed: 20688898
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102
pubmed: 28407145
Cell Mol Life Sci. 2014 Jul;71(14):2577-604
pubmed: 24363178
Cell Rep. 2019 Aug 20;28(8):1949-1960.e6
pubmed: 31433973
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cancer Metab. 2016 Oct 17;4:19
pubmed: 27777765
Mol Cancer Ther. 2008 Dec;7(12):3729-38
pubmed: 19074848
Cancer Metab. 2015 Jan 25;3(1):1
pubmed: 25621173
Mol Genet Metab. 2005 Apr;84(4):305-12
pubmed: 15781190
Diabetes. 2013 Jul;62(7):2183-94
pubmed: 23423574
Nat Commun. 2016 May 10;7:11479
pubmed: 27161491
J Pathol. 2008 Dec;216(4):387-93
pubmed: 18853439
Nat Rev Clin Oncol. 2017 Oct;14(10):611-629
pubmed: 28397828
J Clin Invest. 2015 Feb;125(2):495-7
pubmed: 25607834
J Hematol Oncol. 2017 May 5;10(1):101
pubmed: 28476164
Cell Chem Biol. 2017 Sep 21;24(9):1161-1180
pubmed: 28938091
Cell Rep. 2016 Oct 11;17(3):837-848
pubmed: 27732858
Cell Metab. 2008 Jan;7(1):11-20
pubmed: 18177721
Nat Rev Clin Oncol. 2017 Jan;14(1):11-31
pubmed: 27141887
Cancer Discov. 2016 Dec;6(12):1315-1333
pubmed: 27872127
Nat Chem Biol. 2012 Apr 08;8(5):486-93
pubmed: 22484541
Curr Opin Oncol. 2013 Jan;25(1):50-1
pubmed: 23150341
Mol Cell Proteomics. 2008 Oct;7(10):2019-27
pubmed: 18669619
Dtsch Arztebl Int. 2010 Feb;107(6):85-91
pubmed: 20204119
Nucleic Acids Res. 2010 Jan;38(Database issue):D204-10
pubmed: 20015972
Cell. 2015 Jul 30;162(3):540-51
pubmed: 26232224
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W645-50
pubmed: 16912992
Cancer Invest. 2014 Jul;32(6):241-7
pubmed: 24762082
Mol Cell Oncol. 2015 Jan 07;2(3):e981994
pubmed: 27308459
Science. 2017 May 26;356(6340):
pubmed: 28495876
Oncotarget. 2015 Sep 15;6(27):23720-34
pubmed: 26125441
Curr Opin Cell Biol. 2007 Dec;19(6):612-7
pubmed: 17997088
Mol Genet Metab. 2010 Sep;101(1):9-17
pubmed: 20598931
Curr Pharm Des. 2012;18(17):2464-71
pubmed: 22372504
Mol Cell Biol. 2015 Jan;35(1):2-10
pubmed: 25348713
Carcinogenesis. 2014 Apr;35(4):784-94
pubmed: 24293407
N Engl J Med. 2008 Apr 17;358(16):1663-71
pubmed: 18420499
Pediatr Res. 1979 Feb;13(2):109-16
pubmed: 219411
Neoplasia. 2014 Aug;16(8):665-77
pubmed: 25220594
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8674-9
pubmed: 21555572
Mol Genet Metab Rep. 2014 Nov 28;2:25-31
pubmed: 28649521
Eur J Med Chem. 2015;96:269-80
pubmed: 25899332
PLoS One. 2015 Jun 12;10(6):e0129848
pubmed: 26070193
Cancer Med. 2013 Oct;2(5):611-24
pubmed: 24403227
Nature. 2012 May 31;485(7400):590-1
pubmed: 22660317
Nat Rev Cancer. 2011 Feb;11(2):85-95
pubmed: 21258394
Science. 2017 Aug 18;357(6352):
pubmed: 28818916
Sci Rep. 2016 Feb 24;6:22002
pubmed: 26906558
Biochem J. 2007 Jul 15;405(2):359-67
pubmed: 17408383
Cell Death Differ. 2019 Oct;26(10):1955-1969
pubmed: 30659235
Open Enzym Inhib J. 2010;3:8-26
pubmed: 22180764
Nat Commun. 2015 Nov 02;6:8784
pubmed: 26522426
Biochem J. 2010 Mar 15;427(1):1-17
pubmed: 20226003
Breast Cancer Res. 2013;15(4):R52
pubmed: 23820017
Nat Rev Drug Discov. 2011 Aug 31;10(9):671-84
pubmed: 21878982
Oncogene. 2017 Mar;36(11):1461-1473
pubmed: 27617575
Nat Rev Cancer. 2011 May;11(5):325-37
pubmed: 21508971
J Mol Med (Berl). 2018 Apr;96(3-4):237-247
pubmed: 29362846
Science. 2013 May 3;340(6132):622-6
pubmed: 23558173
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Cell. 2015 Jul 30;162(3):552-63
pubmed: 26232225
J Clin Invest. 2015 Feb;125(2):551-62
pubmed: 25562323
J Biol Chem. 2014 Oct 3;289(40):27937-51
pubmed: 25124032
Genome Res. 2003 Sep;13(9):2129-41
pubmed: 12952881
J Clin Invest. 2015 Feb;125(2):687-98
pubmed: 25607840
Int J Urol. 2007 Nov;14(11):1034-9
pubmed: 17956532
Redox Biol. 2017 Aug;12:833-842
pubmed: 28448945
J Bacteriol. 2010 Apr;192(7):1774-84
pubmed: 20097852
Nat Biotechnol. 2016 Aug 9;34(8):794-5
pubmed: 27504761
Breast Cancer Res. 2018 Jul 13;20(1):76
pubmed: 30005601
Nature. 2010 Apr 15;464(7291):1062-6
pubmed: 20393565