Insomnia and Neurocognitive Functioning in Adult Survivors of Childhood Cancer.
Journal
JNCI cancer spectrum
ISSN: 2515-5091
Titre abrégé: JNCI Cancer Spectr
Pays: England
ID NLM: 101721827
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
19
08
2019
revised:
29
11
2019
accepted:
04
02
2020
entrez:
9
5
2020
pubmed:
10
5
2020
medline:
10
5
2020
Statut:
epublish
Résumé
In noncancer populations, insomnia is known to affect neurocognitive processes. Although the prevalence of insomnia appears to be elevated in survivors of childhood cancer, relatively little is known about its association with neurocognitive performance in this at-risk population. A total of 911 survivors (51.9% female; mean [SD] age, 34 [9.0] years; time since diagnosis, 26 [9.1] years) completed direct assessments of attention, memory, processing speed, and executive functioning and self-reported symptoms of sleep (Pittsburgh Sleep Quality Index), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), and daytime sleepiness (Epworth Sleepiness Scale). Sex-stratified general linear models were used to examine associations between insomnia and neurocognitive performance, with adjustment for treatment exposures and chronic health conditions. All statistical tests were two-sided. Insomnia was reported by 22.1% of females and 12.3% of males ( Insomnia was highly prevalent and contributed to the neurocognitive burden experienced by adult survivors of childhood cancer. Treatment of insomnia may improve neurocognitive problems in survivors.
Sections du résumé
BACKGROUND
BACKGROUND
In noncancer populations, insomnia is known to affect neurocognitive processes. Although the prevalence of insomnia appears to be elevated in survivors of childhood cancer, relatively little is known about its association with neurocognitive performance in this at-risk population.
METHODS
METHODS
A total of 911 survivors (51.9% female; mean [SD] age, 34 [9.0] years; time since diagnosis, 26 [9.1] years) completed direct assessments of attention, memory, processing speed, and executive functioning and self-reported symptoms of sleep (Pittsburgh Sleep Quality Index), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), and daytime sleepiness (Epworth Sleepiness Scale). Sex-stratified general linear models were used to examine associations between insomnia and neurocognitive performance, with adjustment for treatment exposures and chronic health conditions. All statistical tests were two-sided.
RESULTS
RESULTS
Insomnia was reported by 22.1% of females and 12.3% of males (
CONCLUSIONS
CONCLUSIONS
Insomnia was highly prevalent and contributed to the neurocognitive burden experienced by adult survivors of childhood cancer. Treatment of insomnia may improve neurocognitive problems in survivors.
Identifiants
pubmed: 32382693
doi: 10.1093/jncics/pkaa008
pii: pkaa008
pmc: PMC7197383
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pkaa008Subventions
Organisme : NCI NIH HHS
ID : R01 CA239689
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA225590
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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