Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies.

ischemic preconditioning liver transplantation mechanism reperfusion injury therapeutics

Journal

Journal of biomedical research
ISSN: 1674-8301
Titre abrégé: J Biomed Res
Pays: China
ID NLM: 101551157

Informations de publication

Date de publication:
28 Jul 2019
Historique:
entrez: 9 5 2020
pubmed: 10 5 2020
medline: 10 5 2020
Statut: ppublish

Résumé

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation. This review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver transplantation. Pharmacological therapies, the use of pre-and post-conditioning and machine perfusion are discussed as protective strategies. The use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury, and is an exciting and active area of research, which needs more study clinically.

Identifiants

pubmed: 32383437
doi: 10.7555/JBR.32.20180087
pmc: PMC6813524
doi:

Types de publication

Journal Article

Langues

eng

Pagination

221-234

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Auteurs

Sanketh Rampes (S)

Faculty of Life Sciences & Medicine, King's College London, London SE1 1U, UK.

Daqing Ma (D)

Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK.

Classifications MeSH