Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca
Hexokinase 2
anti-neoplastic strategy
cancer
cell penetrating peptide
mitochondria-associated membranes
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
03 07 2020
03 07 2020
Historique:
received:
21
08
2019
revised:
22
03
2020
accepted:
02
04
2020
pubmed:
10
5
2020
medline:
28
4
2021
entrez:
9
5
2020
Statut:
ppublish
Résumé
Cancer cells undergo changes in metabolic and survival pathways that increase their malignancy. Isoform 2 of the glycolytic enzyme hexokinase (HK2) enhances both glucose metabolism and resistance to death stimuli in many neoplastic cell types. Here, we observe that HK2 locates at mitochondria-endoplasmic reticulum (ER) contact sites called MAMs (mitochondria-associated membranes). HK2 displacement from MAMs with a selective peptide triggers mitochondrial Ca
Identifiants
pubmed: 32383545
doi: 10.15252/embr.201949117
pmc: PMC7332982
doi:
Substances chimiques
Hexokinase
EC 2.7.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e49117Subventions
Organisme : JHU|Neurofibromatosis Therapeutic Acceleration Program (NTAP)
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro (AIRC)
ID : IG 2017/20749
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro (AIRC)
ID : 2015/17067
Pays : International
Organisme : Children's Tumor Foundation (CTF)
Pays : International
Organisme : Università degli Studi di Padova
Pays : International
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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