The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
15
07
2019
accepted:
12
03
2020
revised:
19
06
2020
pubmed:
10
5
2020
medline:
18
7
2020
entrez:
9
5
2020
Statut:
epublish
Résumé
The extensive use of insecticides for vector control has led to the development of insecticide resistance in Aedes aegypti populations on a global scale, which has significantly compromised control actions. Insecticide resistance, and its underlying mechanisms, has been investigated in several countries, mostly in South American and Asian countries. In Africa, however, studies reporting insecticide resistance are rare and data on resistance mechanisms, notably knockdown resistance (kdr) mutations, is scarce. In this study, the recently described V410L kdr mutation is reported for the first time in old world Ae. aegypti populations, namely from Angola and Madeira island. Two additional kdr mutations, V1016I and F1534C, are also reported for the first time in populations from Angola and Cape Verde. Significant associations with the resistance phenotype were found for both V410L and V1016I individually as well as for tri-locus genotypes in the Angolan population. However, no association was found in Madeira island, probably due to the presence of a complex pattern of multiple insecticide resistance mechanisms in the local Ae. aegypti population. These results suggest that populations carrying the same kdr mutations may respond differently to the same insecticide, stressing the need for complementary studies when assessing the impact of kdr resistance mechanisms in the outcome of insecticide-based control strategies.
Identifiants
pubmed: 32384079
doi: 10.1371/journal.pntd.0008216
pii: PNTD-D-19-01169
pmc: PMC7304628
doi:
Substances chimiques
Insect Proteins
0
Insecticides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0008216Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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