MSC-Derived Extracellular Vesicles: New Emergency Treatment to Limit the Development of Radiation-Induced Hematopoietic Syndrome?
Animals
Bone Marrow
/ metabolism
Emergency Treatment
/ methods
Extracellular Vesicles
/ metabolism
Granulocyte Colony-Stimulating Factor
/ metabolism
Hematopoiesis
/ radiation effects
Hematopoietic Stem Cell Transplantation
/ methods
Hematopoietic Stem Cells
/ metabolism
Humans
Mesenchymal Stem Cell Transplantation
/ methods
Mesenchymal Stem Cells
/ metabolism
Radiation Dosage
Radiation Exposure
Radiation Injuries
/ therapy
Journal
Health physics
ISSN: 1538-5159
Titre abrégé: Health Phys
Pays: United States
ID NLM: 2985093R
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
10
5
2020
medline:
20
4
2021
entrez:
9
5
2020
Statut:
ppublish
Résumé
Nuclear accidents or acts of terrorism involving radioactive sources might lead to mass casualties irradiation. The hematopoietic system is one of the most critical and radiation-sensitive tissues because the limited life span of blood cells requires the continuous division of hematopoietic stem cells (HSCs) into the bone marrow. The radiation-induced hematopoietic syndrome, RI-HS, is an impairment of the hematopoiesis that will result in pancytopenia of various degrees. In fact, treatment with granulocyte-colony stimulating factor (G-CSF) is considered as a valuable adjunct to treatment controls in some irradiated patients. Nevertheless, these overexposed patients with bone marrow suppression have minimal medullary territories that do not allow complete recovery of hematopoiesis but lead to significant immunoreactivity following allogeneic hematopoietic stem cell transplantation (HSCT). The high morbidity and mortality of these overexposed patients is a reminder of the lack of effective treatment for hematopoietic syndrome. During the last 20 y, a therapeutic approach for mesenchymal stem cells (MSC) has been proposed for the management of accidentally irradiated victims. Many preclinical animal studies have shown that MSC, mainly by their secretory activity, in particular extracellular vesicles (EVs), contribute to the control of inflammation and promote regeneration of tissues by accelerating angiogenesis and re-epithelialization processes. Therefore, we investigated the potential effect of EVs on the reduction of early bone marrow ionization toxicity, early anti-apoptotic therapy, and vascular protection in the RI-HS model. The main purpose is to propose an innovative treatment of non-patient-specific RI-HS emergency treatment in order to limit allogeneic HSC.
Identifiants
pubmed: 32384375
doi: 10.1097/HP.0000000000001264
pii: 00004032-202007000-00004
doi:
Substances chimiques
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-36Références
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