Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Adipocytes
/ metabolism
Adipogenesis
/ physiology
Adipose Tissue, White
/ metabolism
Animals
Calorimetry
Cells, Cultured
Female
Fibroblast Growth Factor 1
/ genetics
Flow Cytometry
Humans
Immunohistochemistry
In Situ Nick-End Labeling
Insulin
/ blood
Interleukin-6
/ blood
Ion Channels
/ genetics
Male
Mice
Receptor, Fibroblast Growth Factor, Type 1
/ genetics
Signal Transduction
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 05 2020
08 05 2020
Historique:
received:
16
10
2019
accepted:
01
04
2020
entrez:
10
5
2020
pubmed:
10
5
2020
medline:
18
8
2020
Statut:
epublish
Résumé
White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis). Adipogenesis results in WAT hyperplasia, smaller adipocytes and a metabolically more favourable form of obesity. How obesogenic WAT hyperplasia is induced remains, however, poorly understood. Here, we show that the mechanosensitive cationic channel Piezo1 mediates diet-induced adipogenesis. Mice lacking Piezo1 in mature adipocytes demonstrated defective differentiation of preadipocyte into mature adipocytes when fed a high fat diet (HFD) resulting in larger adipocytes, increased WAT inflammation and reduced insulin sensitivity. Opening of Piezo1 in mature adipocytes causes the release of the adipogenic fibroblast growth factor 1 (FGF1), which induces adipocyte precursor differentiation through activation of the FGF-receptor-1. These data identify a central feed-back mechanism by which mature adipocytes control adipogenesis during the development of obesity and suggest Piezo1-mediated adipocyte mechano-signalling as a mechanism to modulate obesity and its metabolic consequences.
Identifiants
pubmed: 32385276
doi: 10.1038/s41467-020-16026-w
pii: 10.1038/s41467-020-16026-w
pmc: PMC7211025
doi:
Substances chimiques
Insulin
0
Interleukin-6
0
Ion Channels
0
Piezo1 protein, mouse
0
Fibroblast Growth Factor 1
104781-85-3
Receptor, Fibroblast Growth Factor, Type 1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2303Commentaires et corrections
Type : ErratumIn
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