A limbic circuitry involved in emotional stress-induced grooming.
Animals
Calcium
/ metabolism
Emotions
/ physiology
Grooming
Hippocampus
/ physiopathology
Limbic System
/ physiopathology
Male
Models, Biological
Nerve Net
/ physiopathology
Neurons
/ pathology
Optogenetics
Probability
Rats, Sprague-Dawley
Stress, Psychological
/ physiopathology
Synapses
/ pathology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 05 2020
08 05 2020
Historique:
received:
17
07
2019
accepted:
16
04
2020
entrez:
10
5
2020
pubmed:
10
5
2020
medline:
6
8
2020
Statut:
epublish
Résumé
Prolonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved to respond to stress, including repetitive displacement behaviours, are important in maintaining behavioural homoeostasis. In rodents, self-grooming is a frequently observed repetitive behaviour believed to contribute to post-stress de-arousal with adaptive value. Here we identified a rat limbic di-synaptic circuit that regulates stress-induced self-grooming with positive affective valence. This circuit links hippocampal ventral subiculum to ventral lateral septum (LSv) and then lateral hypothalamus tuberal nucleus. Optogenetic activation of this circuit triggers delayed but robust excessive grooming with patterns closely resembling those evoked by emotional stress. Consistently, the neural activity of LSv reaches a peak before emotional stress-induced grooming while inhibition of this circuit significantly suppresses grooming triggered by emotional stress. Our results uncover a previously unknown limbic circuitry involved in regulating stress-induced self-grooming and pinpoint a critical role of LSv in this ethologically important behaviour.
Identifiants
pubmed: 32385304
doi: 10.1038/s41467-020-16203-x
pii: 10.1038/s41467-020-16203-x
pmc: PMC7210270
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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