Action of Akt Pathway on La-Induced Hippocampal Neuron Apoptosis of Rats in the Growth Stage.
Animals
Apoptosis
/ drug effects
Caspase 3
/ drug effects
Caspase 9
/ drug effects
Hippocampus
/ drug effects
Lanthanum
/ toxicity
Learning
/ drug effects
Memory
/ drug effects
Neurons
/ drug effects
Proto-Oncogene Proteins c-akt
/ drug effects
Proto-Oncogene Proteins c-bcl-2
/ drug effects
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
bcl-2-Associated X Protein
/ drug effects
bcl-Associated Death Protein
/ drug effects
bcl-X Protein
/ drug effects
Akt pathway
Hippocampal neurons
La
Neuronal apoptosis
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
05
02
2020
accepted:
08
04
2020
revised:
04
04
2020
pubmed:
10
5
2020
medline:
16
6
2021
entrez:
10
5
2020
Statut:
ppublish
Résumé
This study investigated the influences of lanthanum (La) exposure on learning and memory and the expression of apoptosis-related proteins in offspring rats. Wistar female rats were randomly divided into a control group (NC) and 0.25%, 0.5% and 1.0% LaCl
Identifiants
pubmed: 32385838
doi: 10.1007/s12640-020-00206-z
pii: 10.1007/s12640-020-00206-z
doi:
Substances chimiques
Bad protein, rat
0
Bax protein, rat
0
Bcl2 protein, rat
0
Bcl2l1 protein, rat
0
Proto-Oncogene Proteins c-bcl-2
0
bcl-2-Associated X Protein
0
bcl-Associated Death Protein
0
bcl-X Protein
0
lanthanum chloride
04M8624OXV
Lanthanum
6I3K30563S
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Casp3 protein, rat
EC 3.4.22.-
Casp9 protein, rat
EC 3.4.22.-
Caspase 3
EC 3.4.22.-
Caspase 9
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
434-446Subventions
Organisme : National Natural Science Foundation of China
ID : 81602891
Organisme : Science Project of Education Department in Province Liaoning
ID : ldxy2017017
Organisme : Program for Liaoning Innovation Talents in University
ID : LR2016053
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