Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function.
Antigens, CD
/ immunology
B7-H1 Antigen
/ immunology
Cell Differentiation
/ drug effects
Cell Line
Female
Humans
Interferon-beta
/ immunology
Lipopolysaccharides
/ pharmacology
Macrophage Activation
Macrophages
/ cytology
Pregnancy
/ immunology
Toll-Like Receptor 4
/ immunology
Trophoblasts
/ cytology
IFN-β
LPS
PD1
Trophoblast
macrophage
soluble PD-L1
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
07
01
2020
revised:
08
04
2020
accepted:
09
04
2020
pubmed:
10
5
2020
medline:
10
2
2021
entrez:
10
5
2020
Statut:
ppublish
Résumé
Decidual macrophages are in close contact with trophoblast cells during placenta development, and an appropriate crosstalk between these cellular compartments is crucial for the establishment and maintenance of a healthy pregnancy. During different phases of gestation, macrophages undergo dynamic changes to adjust to the different stages of fetal development. Trophoblast-secreted factors are considered the main modulators responsible for macrophage differentiation and function. However, the phenotype of these macrophages induced by trophoblast-secreted factors and the factors responsible for their polarization has not been elucidated. In this study, we characterized the phenotype and function of human trophoblast-induced macrophages. Using in vitro models, we found that human trophoblast-educated macrophages were CD14
Identifiants
pubmed: 32386458
doi: 10.1002/JLB.1A0420-012RR
pmc: PMC8190653
mid: NIHMS1608639
doi:
Substances chimiques
Antigens, CD
0
B7-H1 Antigen
0
CD274 protein, human
0
Lipopolysaccharides
0
TLR4 protein, human
0
Toll-Like Receptor 4
0
Interferon-beta
77238-31-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
983-998Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145829
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : 1R01AI145829-01
Pays : United States
Informations de copyright
©2020 Society for Leukocyte Biology.
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