Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation.
cell division
chromosome
dynein
kinetochore
microtubule
spindle assembly checkpoint
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
14
02
2020
revised:
08
04
2020
accepted:
08
04
2020
pubmed:
11
5
2020
medline:
25
6
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known for decades that it can expand and grow a fibrous meshwork known as the corona, it was until recently unclear what constitutes this 'crown' and what its relevance is for kinetochore function. Here, we highlight recent discoveries in fibrous corona biology, and place them in the context of the processes that orchestrate high-fidelity chromosome segregation.
Identifiants
pubmed: 32386879
pii: S0962-8924(20)30092-1
doi: 10.1016/j.tcb.2020.04.006
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
653-667Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.