Cooperation Between Hypoxia-Inducible Factor 1α and Activating Transcription Factor 4 in Sleep Apnea-Mediated Myocardial Injury.
Activating Transcription Factor 4
/ metabolism
Animals
CCAAT-Enhancer-Binding Proteins
/ metabolism
Cell Death
Humans
Hypoxia
/ complications
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Mice
Myocardial Infarction
/ etiology
Myocytes, Cardiac
/ metabolism
Sleep Apnea Syndromes
/ complications
Journal
The Canadian journal of cardiology
ISSN: 1916-7075
Titre abrégé: Can J Cardiol
Pays: England
ID NLM: 8510280
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
17
12
2019
revised:
01
04
2020
accepted:
01
04
2020
pubmed:
11
5
2020
medline:
17
2
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
Chronic intermittent hypoxia (CIH) occurring during sleep apnea amplifies infarct size owing to ischemia-reperfusion. CIH activates hypoxia-inducible factor 1 (HIF-1) and activating transcription factor 4 (ATF4). However, whether HIF-1 and ATF4 interact to promote cardiomyocyte death remains unexplored. For the first time, we observed that in myocardium from apneic patients, CCAAT enhancer-binding protein homologous protein (CHOP) expression is increased and HIF-1α expression is correlated with sleep apnea severity. In mice, single-allele deletion of HIF-1α prevents CIH increase in CHOP expression and infarct size. We uncovered a physical interaction between HIF-1α and ATF4 in CIH that may represent a novel cardiomyocyte death complex.
Identifiants
pubmed: 32387037
pii: S0828-282X(20)30324-X
doi: 10.1016/j.cjca.2020.04.002
pii:
doi:
Substances chimiques
ATF4 protein, human
0
Atf4 protein, mouse
0
CCAAT-Enhancer-Binding Proteins
0
HIF1A protein, human
0
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Activating Transcription Factor 4
145891-90-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
936-940Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.