News ways of understanding the complex biology of diabetes using PET.
Beta cell mass
Diabetes
Hormone receptors
PET
Receptor occupancy
Target distribution
Target engagement
Tracer development
Journal
Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
01
2020
revised:
27
03
2020
accepted:
15
04
2020
pubmed:
11
5
2020
medline:
5
10
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
The understanding of metabolic disease and diabetes on a molecular level has increased significantly due to the recent advances in molecular biology and biotechnology. However, in vitro studies and animal models do not always translate to the human disease, perhaps illustrated by the failure of many drug candidates in the clinical phase. Non-invasive biomedical imaging techniques such as Positron Emission Tomography (PET) offer tools for direct visualization and quantification of molecular processes in humans. Developments in this area potentially enable longitudinal in vivo studies of receptors and processes involved in diabetes guiding drug development and diagnosis in the near future. This mini-review focuses on describing the overall perspective of how PET can be used to increase our understanding and improve treatment of diabetes. The methodological aspects and future developments and challenges are highlighted.
Identifiants
pubmed: 32387114
pii: S0969-8051(20)30016-0
doi: 10.1016/j.nucmedbio.2020.04.004
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-71Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.