Can BRET-based biosensors be used to characterize G-protein mediated signaling pathways of an insect GPCR, the Schistocerca gregaria CRF-related diuretic hormone receptor?
BRET
Cyclic AMP
G protein-coupled receptor
Insect
Neuropeptide
Reporter assay
Journal
Insect biochemistry and molecular biology
ISSN: 1879-0240
Titre abrégé: Insect Biochem Mol Biol
Pays: England
ID NLM: 9207282
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
27
11
2019
revised:
01
04
2020
accepted:
19
04
2020
pubmed:
11
5
2020
medline:
5
1
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
G protein-coupled receptors (GPCRs) are membrane-bound receptors that are considered prime candidates for the development of novel insect pest management strategies. However, the molecular signaling properties of insect GPCRs remain poorly understood. In fact, most studies on insect GPCR signaling are limited to analysis of fluctuations in the secondary messenger molecules calcium (Ca
Identifiants
pubmed: 32387240
pii: S0965-1748(20)30081-3
doi: 10.1016/j.ibmb.2020.103392
pii:
doi:
Substances chimiques
Insect Hormones
0
Insect Proteins
0
Receptors, G-Protein-Coupled
0
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103392Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.