The CoV-2 outbreak: how hematologists could help to fight Covid-19.
Baricitinib
Begelomab
COVID-19
GVHD
MAS
Ruxolitinib
TKIs
Tocilizumab
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
03
04
2020
revised:
24
04
2020
accepted:
26
04
2020
pubmed:
11
5
2020
medline:
1
7
2020
entrez:
11
5
2020
Statut:
ppublish
Résumé
COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). Hematologists are confident with these situations requiring a prompt therapeutic approach for switching off the uncontrolled cytokine release; here, we discuss pros and cons of drugs that are already employed in hematology in the light of their possible application in COVID-19. The most promising drugs might be: Ruxolitinib, a JAK1/2 inhibitor, with a rapid and powerful anti-cytokine effect, tyrosine kinase inhibitors (TKIs), with their good anti-inflammatory properties, and perhaps the anti-Cd26 antibody Begelomab. We also present immunological data from gene expression experiments where TKIs resulted effective anti-inflammatory and pro-immune drugs. A possible combined treatment algorithm for COVID-19 is here proposed.
Identifiants
pubmed: 32387301
pii: S1043-6618(20)31174-9
doi: 10.1016/j.phrs.2020.104866
pmc: PMC7202852
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104866Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest S. Galimberti, C. Baratè and M. Petrini were speakers in the events supported by Novartis, Pfizer, Celgene/BMS, Janssen, Roche, Incyte and members of advisory boards for Novartis and Janssen; A. Di Paolo was a speaker for Medac GmbH, Novartis, Roche, Incyte, and was an advisory board member for Novartis; C. Baldini and F. Ferro do not have any conflict of interest.
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