Differences in failure patterns according to the EGFR mutation status after proton beam therapy for early stage non-small cell lung cancer.

Carcinoma, Non-Small-Cell Lung / genetics ErbB Receptors / genetics Humans Lung Neoplasms / genetics Mutation Neoplasm Staging Proton Therapy
EGFR Early NSCLC Proton

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
08 2020
Historique:
received: 02 01 2020
revised: 09 04 2020
accepted: 29 04 2020
pubmed: 11 5 2020
medline: 15 4 2021
entrez: 11 5 2020
Statut: ppublish

Résumé

We analyzed 135 patients (including 27 EGFR-mutant and 29 EGFR-wild) with T1-3N0M0 non-squamous NSCLC treated by PBT. Considering the 3-year cumulative incidence, the EGFR-mutant group showed a significantly lower infield failure rate (9% vs 27%, p = 0.02) and higher out-of-field failure rate (67% vs 40%, p = 0.02) than the EGFR-wild group.

Identifiants

DOI: 10.1016/j.radonc.2020.04.056 PMID: 32387485
pubmed: 32387485
pii: S0167-8140(20)30237-1
doi: 10.1016/j.radonc.2020.04.056
pii:
doi:

Substances chimiques

EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14-17

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Masaki Nakamura (M)

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan. Electronic address: masanaka@east.ncc.go.jp.

Shun-Ichiro Kageyama (SI)

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan.

Hibiki Udagawa (H)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Yoshitaka Zenke (Y)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Kiyotaka Yoh (K)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Seiji Niho (S)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Hidehiro Hojo (H)

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan.

Atsushi Motegi (A)

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan.

Keisuke Kirita (K)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Singo Matsumoto (S)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Koichi Goto (K)

Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Tetsuo Akimoto (T)

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Chiba, Japan.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Differences in failure patterns according to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Differences in failure patterns according to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differences in failure patterns according to...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Differences in failure patterns according to...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Differences in failure patterns according to...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Differences in failure patterns according to...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Protonthérapie › Differences in failure patterns according to...