Hypertension during Diabetic Ketoacidosis in Children.
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
15
01
2020
revised:
15
04
2020
accepted:
28
04
2020
pubmed:
11
5
2020
medline:
2
12
2020
entrez:
11
5
2020
Statut:
ppublish
Résumé
To characterize hemodynamic alterations occurring during diabetic ketoacidosis (DKA) in a large cohort of children and to identify clinical and biochemical factors associated with hypertension. This was a planned secondary analysis of data from the Pediatric Emergency Care Applied Research Network Fluid Therapies Under Investigation in DKA Study, a randomized clinical trial of fluid resuscitation protocols for children in DKA. Hemodynamic data (heart rate, blood pressure) from children with DKA were assessed in comparison with normal values for age and sex. Multivariable statistical modeling was used to explore clinical and laboratory predictors of hypertension. Among 1258 DKA episodes, hypertension was documented at presentation in 154 (12.2%) and developed during DKA treatment in an additional 196 (15.6%), resulting in a total of 350 DKA episodes (27.8%) in which hypertension occurred at some time. Factors associated with hypertension at presentation included more severe acidosis, (lower pH and lower pCO Despite dehydration, hypertension occurs in a substantial number of children with DKA. Factors associated with hypertension include greater severity of acidosis, lower pCO
Identifiants
pubmed: 32387716
pii: S0022-3476(20)30570-9
doi: 10.1016/j.jpeds.2020.04.066
pmc: PMC7414786
mid: NIHMS1591461
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
156-163.e5Subventions
Organisme : NICHD NIH HHS
ID : U01 HD062417
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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