Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate.
3T3 Cells
Acetazolamide
/ chemistry
Animals
Carbonic Anhydrase I
/ antagonists & inhibitors
Carbonic Anhydrase II
/ antagonists & inhibitors
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Catalytic Domain
Cations, Divalent
/ chemistry
Cell Survival
/ drug effects
Humans
Kinetics
Mice
Molecular Conformation
Molecular Docking Simulation
Structure-Activity Relationship
Sulfonamides
/ chemical synthesis
Thiocarbamates
/ chemistry
Zinc
/ chemistry
Carbonic anhydrase
Cytotoxicity
Dithiocarbamate
Molecular docking
Sulfonamide
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
18
03
2020
revised:
16
04
2020
accepted:
25
04
2020
pubmed:
11
5
2020
medline:
27
1
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. The IC
Identifiants
pubmed: 32388113
pii: S0223-5234(20)30362-7
doi: 10.1016/j.ejmech.2020.112392
pii:
doi:
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Cations, Divalent
0
Sulfonamides
0
Thiocarbamates
0
Carbonic Anhydrase I
EC 4.2.1.-
Carbonic Anhydrase II
EC 4.2.1.-
Zinc
J41CSQ7QDS
Acetazolamide
O3FX965V0I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112392Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.