Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia.
Diagnostic
PlGF
Pre-eclampsia
Test performance
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
09
03
2020
revised:
11
04
2020
accepted:
20
04
2020
pubmed:
11
5
2020
medline:
28
5
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks' gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsiarequiring delivery within 14 days (specificity 95.0% (95% CI 91.7-97.2%), positive predictive value50 (95% CI 30.6-69.4%), positive likelihood ratio 10.7 (5.8-20).
Identifiants
pubmed: 32388118
pii: S2210-7789(20)30043-X
doi: 10.1016/j.preghy.2020.04.005
pii:
doi:
Substances chimiques
Biomarkers
0
PGF protein, human
0
Placenta Growth Factor
144589-93-5
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-37Subventions
Organisme : Department of Health
ID : RP-2014-05-019
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.