Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number.
Air pollution
Leukocyte
Mitochondrial DNA copy number
Oxidative stress
PM(2.5)
Particulate matter
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
17
01
2020
revised:
07
04
2020
accepted:
22
04
2020
pubmed:
11
5
2020
medline:
15
12
2020
entrez:
11
5
2020
Statut:
ppublish
Résumé
Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to oxidative stress, are less studied. To investigate the associations between short-, intermediate- and long-term exposure (1-, 3- and 12-months) to different size fractions of PM (PM The associations between each of the PM exposure metrics with z scores of log-transformed mtDNAcn were examined using generalized linear regression models in 2758 female participants from the Nurses' Health Study (NHS). Monthly exposures to PM were estimated from spatio-temporal prediction models matched to each participants' address history. Potential effect modification by selected covariates was examined using multiplicative interaction terms and subgroup analyses. In single-size fraction models, increases in all size fractions of PM were associated with decreases in mtDNAcn, although only models with longer averages of PM Our study suggests that long-term exposure to ambient PM
Sections du résumé
BACKGROUND
Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to oxidative stress, are less studied.
OBJECTIVES
To investigate the associations between short-, intermediate- and long-term exposure (1-, 3- and 12-months) to different size fractions of PM (PM
METHODS
The associations between each of the PM exposure metrics with z scores of log-transformed mtDNAcn were examined using generalized linear regression models in 2758 female participants from the Nurses' Health Study (NHS). Monthly exposures to PM were estimated from spatio-temporal prediction models matched to each participants' address history. Potential effect modification by selected covariates was examined using multiplicative interaction terms and subgroup analyses.
RESULTS
In single-size fraction models, increases in all size fractions of PM were associated with decreases in mtDNAcn, although only models with longer averages of PM
CONCLUSIONS
Our study suggests that long-term exposure to ambient PM
Identifiants
pubmed: 32388147
pii: S0160-4120(20)30098-2
doi: 10.1016/j.envint.2020.105761
pmc: PMC7419671
mid: NIHMS1591915
pii:
doi:
Substances chimiques
Air Pollutants
0
DNA, Mitochondrial
0
Particulate Matter
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105761Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES028033
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES017017
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Environ Sci Technol. 2019 May 21;53(10):5966-5976
pubmed: 31041867
Environ Toxicol. 2013 Feb;28(2):76-86
pubmed: 21384498
Circulation. 2016 Jan 26;133(4):378-87
pubmed: 26660284
Cell J. 2018 Oct;20(3):396-402
pubmed: 29845794
JAMA Cardiol. 2017 Nov 1;2(11):1247-1255
pubmed: 29049454
Carcinogenesis. 2016 Sep;37(9):897-903
pubmed: 27381830
Biogerontology. 2014;15(5):417-38
pubmed: 25015781
Neuro Oncol. 2019 Apr 26;:
pubmed: 31095694
Environ Int. 2017 Jan;98:198-203
pubmed: 27843010
Cancer Causes Control. 1995 May;6(3):217-24
pubmed: 7612801
Toxicol Lett. 2011 May 10;202(3):209-17
pubmed: 21371539
Lancet. 2013 Jun 8;381(9882):1987-2015
pubmed: 23746901
Cardiovasc Toxicol. 2010 Sep;10(3):216-26
pubmed: 20668962
Environ Pollut. 2018 Mar;234:406-419
pubmed: 29202419
Environ Health Perspect. 2016 Jul;124(7):943-50
pubmed: 26672058
J Am Heart Assoc. 2015 Nov 25;4(12):
pubmed: 26607712
Chemosphere. 2019 Mar;218:577-588
pubmed: 30502696
Biochim Biophys Acta. 2015 Nov;1847(11):1347-53
pubmed: 26050973
Carcinogenesis. 2019 Dec 31;40(12):1462-1468
pubmed: 31556446
Environ Mol Mutagen. 2008 Jul;49(6):453-7
pubmed: 18481315
Medicine (Baltimore). 2016 Feb;95(7):e2717
pubmed: 26886611
Biogerontology. 2019 Dec;20(6):741-761
pubmed: 31473864
Lancet. 2014 Mar 1;383(9919):785-95
pubmed: 24332274
Circ Res. 2012 Apr 13;110(8):1109-24
pubmed: 22499901
Diabetes. 2013 Oct;62(10):3488-99
pubmed: 23863811
J Biomed Sci. 2000 Jan-Feb;7(1):2-15
pubmed: 10644884
Environ Health. 2014 Aug 05;13:63
pubmed: 25097007
Mitochondrion. 2014 May;16:73-82
pubmed: 23851045
Environ Health Perspect. 2009 Jul;117(7):1065-9
pubmed: 19654914
Free Radic Biol Med. 2015 May;82:73-104
pubmed: 25640729
J Am Coll Cardiol. 2017 Jul 11;70(2):230-251
pubmed: 28683970
Ecotoxicol Environ Saf. 2019 Oct 30;182:109384
pubmed: 31272023
Nucleic Acids Res. 2009 Feb;37(3):749-61
pubmed: 19074198
Nucleic Acids Res. 2003 Jul 15;31(14):3909-17
pubmed: 12853606
Carcinogenesis. 2017 Sep 1;38(9):893-899
pubmed: 28911003
Int J Environ Res Public Health. 2018 Dec 22;16(1):
pubmed: 30583542
Part Fibre Toxicol. 2013 Apr 29;10:17
pubmed: 23628000
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Oct-Dec;26(4):339-62
pubmed: 19034792
Kidney Int. 2019 Aug;96(2):480-488
pubmed: 31248648
Biofactors. 2020 Jan;46(1):5-20
pubmed: 31580521
Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:133-66
pubmed: 25475422
Am J Public Health. 2016 Sep;106(9):1528-9
pubmed: 27509274
Environ Int. 2018 Mar;112:261-268
pubmed: 29306794
PLoS One. 2015 Sep 22;10(9):e0138716
pubmed: 26394041
Environ Sci Technol. 2017 Jul 18;51(14):8185-8195
pubmed: 28636816
Environ Pollut. 2016 Jan;208(Pt A):16-24
pubmed: 26074023
Environ Pollut. 2020 Mar;258:113648
pubmed: 31806467
J Am Soc Nephrol. 2016 Aug;27(8):2467-73
pubmed: 26794963
Oncotarget. 2016 Sep 13;7(37):60676-60686
pubmed: 27367031
Inhal Toxicol. 2013 Nov;25(13):747-57
pubmed: 24255952
Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):209-18
pubmed: 14977182
J Cell Sci. 2007 Nov 15;120(Pt 22):4025-34
pubmed: 17971411
J Mol Med (Berl). 2015 Feb;93(2):177-186
pubmed: 25471480
Am J Epidemiol. 2017 Oct 15;186(8):961-969
pubmed: 28541385
Part Fibre Toxicol. 2005 Aug 17;2:4
pubmed: 16105184
Am J Clin Nutr. 2019 Feb 1;109(2):424-432
pubmed: 30721920
J Toxicol Environ Health B Crit Rev. 2012;15(1):1-21
pubmed: 22202227
Lancet Oncol. 2013 Aug;14(9):813-22
pubmed: 23849838
Neurobiol Aging. 2018 Mar;63:120-127
pubmed: 29257976
BMC Genomics. 2018 Oct 16;19(1):752
pubmed: 30326835
Mitochondrion. 2014 Jul;17:164-81
pubmed: 24704805
Oncotarget. 2016 May 10;7(19):27307-12
pubmed: 27036024
Environ Sci Technol. 2014 Jul 1;48(13):7576-83
pubmed: 24873754
Environ Sci Technol. 2017 Sep 5;51(17):9846-9855
pubmed: 28758398
Medicine (Baltimore). 2016 Apr;95(15):e3323
pubmed: 27082579
Environ Health Perspect. 2016 Jan;124(1):23-9
pubmed: 25978701
Prog Mol Biol Transl Sci. 2014;127:29-62
pubmed: 25149213
Int J Biochem Cell Biol. 2005 Apr;37(4):822-34
pubmed: 15694841
Epidemiology. 2017 Nov;28(6):763-770
pubmed: 28953603
Environ Health. 2010 Aug 09;9:48
pubmed: 20696069
Environ Toxicol Pharmacol. 2015 Sep;40(2):375-87
pubmed: 26245811
Environ Health Perspect. 2016 Sep;124(9):1414-20
pubmed: 27177127
Environ Health Perspect. 2012 Sep;120(9):1346-52
pubmed: 22626541