Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Antineoplastic Agents
/ chemistry
Drug Resistance, Neoplasm
/ drug effects
Humans
Monocarboxylic Acid Transporters
/ antagonists & inhibitors
Muscle Proteins
/ antagonists & inhibitors
Neoplasms
/ drug therapy
Pyrimidinones
/ chemistry
Structure-Activity Relationship
Symporters
/ antagonists & inhibitors
Thiophenes
/ chemistry
Uracil
/ analogs & derivatives
Cancer
Hypoxia
Monocarboxylate transporter 1 (MCT1)
Monocarboxylate transporter 4 (MCT4)
Multidrug resistance
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Aug 2020
01 Aug 2020
Historique:
received:
10
03
2020
revised:
24
04
2020
accepted:
25
04
2020
pubmed:
11
5
2020
medline:
2
2
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
Development of multidrug resistance (MDR) is one of the major causes leading to failure of cancer chemotherapy and radiotherapy. Monocarboxylate transporters (MCTs) MCT1 and MCT4, which are overexpressed in solid tumours, play a very important role in cancer cell survival and proliferation. These lactate transporters work complimentarily to drive lactate shuttle in tumour cells, which results in maintenance of H
Identifiants
pubmed: 32388280
pii: S0223-5234(20)30363-9
doi: 10.1016/j.ejmech.2020.112393
pii:
doi:
Substances chimiques
AR C155858
0
AZD3965
0
Antineoplastic Agents
0
Monocarboxylic Acid Transporters
0
Muscle Proteins
0
Pyrimidinones
0
SLC16A4 protein, human
0
Symporters
0
Thiophenes
0
monocarboxylate transport protein 1
0
Uracil
56HH86ZVCT
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112393Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.