Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.
Alzheimer’s disease
Brain aging
Cognitive decline
Cognitive testing
Longitudinal studies
Psychometric cognition
Journal
Dementia and geriatric cognitive disorders
ISSN: 1421-9824
Titre abrégé: Dement Geriatr Cogn Disord
Pays: Switzerland
ID NLM: 9705200
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
02
2020
accepted:
16
03
2020
pubmed:
11
5
2020
medline:
26
1
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
We have described the clinical stages of the brain aging and Alzheimer's disease (AD) continuum. In terms of the pre-dementia stages of AD, we introduced the terminology "mild cognitive impairment" (MCI) for the first pre-dementia stage and "subjective cognitive decline" (SCD) for the pre-MCI stage. We now report the characteristics of a pre-SCD condition eventuating in likely AD. The aim of this study was to characterize a pre-SCD condition eventuating in AD. Sixty healthy persons with "no cognitive decline" (NCD) were recruited and 47 were followed (mean baseline age, 64.1 ± 8.9 years; mean follow-up time, 6.7 ± 3.1 years). Outcome was determined at the final assessment prior to 2002 as "decliner," if SCD or worse, or "nondecliner" if NCD. After controlling for age, gender, years of education, and follow-up time, there was a between-group difference in the decline rate (p < 0.001). Also, after controlling for demographic variables and follow-up time, the combinatorial psychometric score was lower at baseline in the future decliners (p = 0.035). Of the 9 psychometric variables, after controlling for demographic variables and follow-up time, 3 were significantly lower at baseline in future decliners. Since AD is known to be age related and all subjects in this study were otherwise healthy, we also did an analysis without controlling for age. The combinatorial psychometric score was highly significantly better at baseline in the future nondecliners than in the future decliners (p = 0.008). This is ostensibly the first study to link psychometric cognitive decline to the subsequent SCD stage of eventual AD.
Sections du résumé
BACKGROUND
We have described the clinical stages of the brain aging and Alzheimer's disease (AD) continuum. In terms of the pre-dementia stages of AD, we introduced the terminology "mild cognitive impairment" (MCI) for the first pre-dementia stage and "subjective cognitive decline" (SCD) for the pre-MCI stage. We now report the characteristics of a pre-SCD condition eventuating in likely AD.
OBJECTIVE
The aim of this study was to characterize a pre-SCD condition eventuating in AD.
METHOD
Sixty healthy persons with "no cognitive decline" (NCD) were recruited and 47 were followed (mean baseline age, 64.1 ± 8.9 years; mean follow-up time, 6.7 ± 3.1 years). Outcome was determined at the final assessment prior to 2002 as "decliner," if SCD or worse, or "nondecliner" if NCD.
RESULTS
After controlling for age, gender, years of education, and follow-up time, there was a between-group difference in the decline rate (p < 0.001). Also, after controlling for demographic variables and follow-up time, the combinatorial psychometric score was lower at baseline in the future decliners (p = 0.035). Of the 9 psychometric variables, after controlling for demographic variables and follow-up time, 3 were significantly lower at baseline in future decliners. Since AD is known to be age related and all subjects in this study were otherwise healthy, we also did an analysis without controlling for age. The combinatorial psychometric score was highly significantly better at baseline in the future nondecliners than in the future decliners (p = 0.008).
CONCLUSION
This is ostensibly the first study to link psychometric cognitive decline to the subsequent SCD stage of eventual AD.
Identifiants
pubmed: 32388509
pii: 000507286
doi: 10.1159/000507286
pmc: PMC8846443
mid: NIHMS1585407
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-21Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000096
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH043486
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR029893
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008051
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG012101
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG003051
Pays : United States
Informations de copyright
© 2020 S. Karger AG, Basel.
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