Pregnancy and non-pregnancy related immune thrombotic thrombocytopenic purpura in women of reproductive age.
Immune
Outcomes
Pregnancy
Reproductive-age
Thrombotic thrombocytopenic purpura
Journal
Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
pubmed:
11
5
2020
medline:
21
10
2021
entrez:
11
5
2020
Statut:
ppublish
Résumé
Pregnancy is a precipitating factor for immune thrombotic thrombocytopenic purpura (iTTP). We compared the clinical course and outcomes of iTTP in women of reproductive age, between those with pregnancy- and non-pregnancy-related iTTP. A review of all reproductive-aged women diagnosed with iTTP during 2010-2019 in seven university hospitals in Israel. Of 42 cases of iTTP, 12 (28.6%) were pregnancy-related. At presentation, the laboratory profiles did not differ significantly between those with pregnancy- and non-pregnancy-related iTTP, including hemoglobin (median 8.4 vs 8.0 g/dL), platelet count (12.5 vs. 11.5 X 10
Identifiants
pubmed: 32388825
doi: 10.1007/s11239-020-02133-4
pii: 10.1007/s11239-020-02133-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-193Références
Scully M, Thomas M, Underwood M et al (2014) Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes. Blood 124:211–219
doi: 10.1182/blood-2014-02-553131
Tsai HM, Lian EC (1998) Antibodies to von Willebrand factorcleavingprotease in acute thrombotic thrombocytopenic purpura. N Engl J Med 339:1585–1594
doi: 10.1056/NEJM199811263392203
Furlan M, Robles R, Galbusera M et al (1998) Von willebrand factor-cleavingprotease in thrombotic thrombocytopenic purpura and thehemolytic-uremic syndrome. N Engl J Med 339(22):1578–1584
doi: 10.1056/NEJM199811263392202
Vesely SK (2015) Life after acquired thrombotic thrombocytopenic purpura: morbidity, mortality, and risks during pregnancy. J Thromb Haemost 1:S216–S222
doi: 10.1111/jth.12953
Ferrari B, Maino A, Lotta LA et al (2014) Pregnancy complications in acquired thrombotic thrombocytopenic purpura: a case-control study. Orphanet J Rare Dis 9:193
doi: 10.1186/s13023-014-0193-6
Moatti-Cohen M, Garrec C, Wolf M et al (2012) French reference center for thrombotic microangiopathies. Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura. Blood 119(24):5888–5897
doi: 10.1182/blood-2012-02-408914
von Auer C, von Krogh AS, Kremer Hovinga JA, Lämmle B (2015) Current insights into thrombotic microangiopathies: thrombotic thrombocytopenic purpura and pregnancy. Thromb Res 1:S30–S33
doi: 10.1016/S0049-3848(15)50437-4
Sanchez-Luceros A, Farias CE, Amaral MM et al (2004) von Willebrand factor cleaving protease (ADAMTS13) activity in normal non-pregnant women, pregnant and post-delivery women. Thromb Haemost 92:1320–1326
doi: 10.1160/TH03-11-0683
Mannucci PM, Canciani MT, Forza I, Lussana F, Lattuada A, Rossi E (2001) Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood 98:2730–2735
doi: 10.1182/blood.V98.9.2730
Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA, Canadian Apheresis Study Group (1991) Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med 325(6):393–397
doi: 10.1056/NEJM199108083250604
Scully M, Hunt BJ, Benjamin S, British Committee for Standards in Haematology et al (2012) Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol 158:323–335
doi: 10.1111/j.1365-2141.2012.09167.x
Scully M, Cataland S, Coppo P et al (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost 15(2):312–322
doi: 10.1111/jth.13571
ACOG Practice Bulletin No. 202 (2019) Gestational hypertension and preeclampsia. Obstet Gynecol 133(1):e1–e25
Dollberg S, Haklai Z, Mimouni FB, Gorfein I, Gordon ES (2005) Birth weight standards in the live-born population in Israel. Isr Med Assoc J 7:311–314
pubmed: 15909464
Prevel R, Roubaud-Baudron C, Gourlain S et al (2019) Immune thrombotic thrombocytopenic purpura in older patients: prognosis and long-term survival. Blood 134(24):2209–2217
doi: 10.1182/blood.2019000748
Benhamou Y, Boelle PY, Baudin B et al (2015) Cardiac troponin-I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic Microangiopathies Reference Center. J Thromb Haemost 13(2):293–302
doi: 10.1111/jth.12790
Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y (2007) The role of the immunesystem in preeclampsia. Mol Aspects Med 28(2):192–209
doi: 10.1016/j.mam.2007.02.006
Sarno L, Stefanovic V, Maruotti GM, Zullo F, Martinelli P (2019) Thrombotic microangiopathies during pregnancy: the obstetrical and neonatal perspective. Eur J Obstet Gynecol Reprod Biol 237:7–12
doi: 10.1016/j.ejogrb.2019.03.018
Zheng L, Zhang D, Cao W, Song WC, Zheng XL (2019) Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy. Blood 134(13):1095–1105
doi: 10.1182/blood.2019001040
Réti M, Farkas P, Csuka D et al (2012) Complement activation in thrombotic thrombocytopenic purpura. J Thromb Haemost 10(5):791–798
doi: 10.1111/j.1538-7836.2012.04674.x
Teirilä L, Heikkinen-Eloranta J, Kotimaa J, Meri S, Lokki AI (2019) Regulation of the complement system and immunological tolerance in pregnancy. Semin Immunol 45:101337
doi: 10.1016/j.smim.2019.101337
Lisonkova S, Joseph KS (2013) Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol 209:544.e1–544.e12
doi: 10.1016/j.ajog.2013.08.019
George JN, Nester CM, McIntosh JJ (2015) Syndromes of thrombotic microangiopathy associated with pregnancy. Hematology Am Soc Hematol Educ Program. 2015:644–648
doi: 10.1182/asheducation-2015.1.644