Inflammation in Hypertension.
Antigen-Presenting Cells
/ metabolism
Cell Communication
/ physiology
Complement System Proteins
/ metabolism
Endothelium, Vascular
/ physiopathology
Humans
Hypertension
/ metabolism
Immunity, Innate
/ physiology
Inflammasomes
/ metabolism
Inflammation
/ physiopathology
Leukocytes
/ metabolism
Myeloid Cells
/ metabolism
Reactive Oxygen Species
/ metabolism
Journal
The Canadian journal of cardiology
ISSN: 1916-7075
Titre abrégé: Can J Cardiol
Pays: England
ID NLM: 8510280
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
03
12
2019
revised:
26
12
2019
accepted:
02
01
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
16
2
2021
Statut:
ppublish
Résumé
For more than 50 years, evidence has accumulated that inflammation contributes to the pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of hypertensive humans. Biomarkers of inflammation, including high sensitivity C-reactive protein, various cytokines, and products of the complement pathway are elevated in humans with hypertension. Emerging evidence suggests that hypertension is accompanied and indeed initiated by activation of complement, the inflammasome, and by a change in the phenotype of circulating immune cells, particularly myeloid cells. High-dimensional transcriptomic analyses are providing insight into new subclasses of immune cells that are likely injurious in hypertension. These inflammatory events are interdependent and there is ultimately engagement of the adaptive immune system through mechanisms involving oxidative stress, modification of endogenous proteins, and alterations in antigen processing and presentation. These observations suggest new therapeutic opportunities to reduce end organ damage in hypertension might be used and guided by levels of inflammatory biomarkers.
Identifiants
pubmed: 32389337
pii: S0828-282X(20)30048-9
doi: 10.1016/j.cjca.2020.01.013
pmc: PMC7733126
mid: NIHMS1582917
pii:
doi:
Substances chimiques
Inflammasomes
0
Reactive Oxygen Species
0
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
635-647Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL129941
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140016
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL144446
Pays : United States
Informations de copyright
Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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