Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.
Adolescent
Body Mass Index
Cardiovascular Diseases
/ epidemiology
Child
Comorbidity
Echocardiography
Female
Heart Ventricles
/ diagnostic imaging
Humans
Hypertrophy, Left Ventricular
/ diagnostic imaging
Longitudinal Studies
Male
Organ Size
Pediatric Obesity
/ epidemiology
Renal Insufficiency, Chronic
/ epidemiology
Risk Factors
Severity of Illness Index
Sex Factors
United States
/ epidemiology
Cardiovascular disease (CVD)
adiposity
adolescents
body mass index (BMI)
cardiac target organ damage
children
chronic kidney disease (CKD)
hypertension
left ventricular hypertrophy (LVH)
left ventricular mass index (LVMI)
obesity
overweight
pediatrics
sex differences
youth
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
09
09
2019
accepted:
17
01
2020
pubmed:
12
5
2020
medline:
6
10
2020
entrez:
12
5
2020
Statut:
ppublish
Résumé
Traditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex. Prospective cohort study. Children with mild-to-moderate CKD enrolled in the Chronic Kidney Disease in Children (CKiD) Study at 49 pediatric nephrology centers across North America. Age- and sex-specific body mass index (BMI) z score. Age- and sex-specific left ventricular mass index (LVMI) z score and left ventricular hypertrophy (LVH). Longitudinal analyses using mixed-effects models to estimate sex-specific associations of BMI z scores with LVMI z score and with LVH, accounting for repeated measurements over time. Among 725 children with 2,829 person-years of follow-up, median age was 11.0 years and median estimated glomerular filtration rate was 52.6mL/min/1.73m Not all children had repeated measurements. LVH is a surrogate and not a hard cardiac outcome. The observational design limits causal inference. In children, adiposity is independently associated with the markers of cardiac damage, LVMI z score and LVH. This association is stronger among girls than boys. Pediatric overweight and obesity may therefore have a substantial impact on cardiovascular risk among children with CKD.
Identifiants
pubmed: 32389356
pii: S0272-6386(20)30547-3
doi: 10.1053/j.ajkd.2020.01.011
pmc: PMC7387195
mid: NIHMS1572393
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-173Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK066143
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK066174
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK066116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL139620
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL119622
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK082194
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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