From SARS to COVID-19: What we have learned about children infected with COVID-19.
Adolescent
Betacoronavirus
/ pathogenicity
COVID-19
Child
Child, Preschool
Coronavirus Infections
/ diagnosis
Humans
Infant
Infant, Newborn
Pandemics
Pneumonia, Viral
/ diagnosis
Severe acute respiratory syndrome-related coronavirus
/ pathogenicity
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ diagnosis
2019-nCoV
COVID-19
Children
Coronavirus
SARS
SARS-CoV-2
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
31
03
2020
revised:
29
04
2020
accepted:
30
04
2020
pubmed:
12
5
2020
medline:
30
7
2020
entrez:
12
5
2020
Statut:
ppublish
Résumé
Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 (COVID-19) is still limited. This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical characteristics and pathogenesis, to further understand the features of COVID-19. By comparing these two diseases, it found that COVID-19 has quicker and wider transmission, obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19 could have severe complications. The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. Based on these early observations, as pediatricians, this review put forward some thoughts on children's COVID-19 and gave some recommendations to contain the disease.
Identifiants
pubmed: 32389849
pii: S1201-9712(20)30309-X
doi: 10.1016/j.ijid.2020.04.090
pmc: PMC7204709
pii:
doi:
Types de publication
Comparative Study
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
710-714Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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