Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds.

Antineoplastic Agents / chemical synthesis Cell Line, Tumor Cell Proliferation / drug effects Cisplatin / pharmacology Coordination Complexes / chemical synthesis Drug Screening Assays, Antitumor Ferrous Compounds / chemistry Humans Triazoles / chemistry Zinc / chemistry

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
11 Jun 2020
Historique:
pubmed: 12 5 2020
medline: 22 1 2021
entrez: 12 5 2020
Statut: ppublish

Résumé

Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

Identifiants

DOI: 10.1039/d0cc02429e PMID: 32390012
pubmed: 32390012
doi: 10.1039/d0cc02429e
doi:

Substances chimiques

Antineoplastic Agents 0
Coordination Complexes 0
Ferrous Compounds 0
Triazoles 0
Zinc J41CSQ7QDS
Cisplatin Q20Q21Q62J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6392-6395

Auteurs

Hualong Song (H)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0002-8980-662X

Nicola J Rogers (NJ)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0002-9604-5136

Viktor Brabec (V)

The Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61265 Brno, Czech Republic. brabec@ibp.cz.
ORCID: 0000-0002-8233-1393

Guy J Clarkson (GJ)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0003-3076-3191

James P C Coverdale (JPC)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0002-7779-6620

Hana Kostrhunova (H)

The Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61265 Brno, Czech Republic. brabec@ibp.cz.
ORCID: 0000-0003-2706-6491

Roger M Phillips (RM)

School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.
ORCID: 0000-0003-3504-177X

Miles Postings (M)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0003-4933-3052

Samantha L Shepherd (SL)

School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.
ORCID: 0000-0002-1395-1011

Peter Scott (P)

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. nicola.rogers@warwick.ac.uk peter.scott@warwick.ac.uk.
ORCID: 0000-0002-5656-7060

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Triazole-based, optically-pure...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Triazole-based, optically-pure...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Triazole-based, optically-pure...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › Triazole-based, optically-pure...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Triazole-based, optically-pure...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Triazole-based, optically-pure...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer II › Triazole-based, optically-pure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Triazole-based, optically-pure...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Triazole-based, optically-pure...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Triazole-based, optically-pure...