A National Consensus Survey for Current Practice in Brain Tumor Management III: Brain Metastasis and Primary Central Nervous System Lymphoma.
Brain tumors
Korean Society for Neuro-Oncology
Lymphoma, Guideline Working Group
Metastasis
Practice patterns
Journal
Brain tumor research and treatment
ISSN: 2288-2405
Titre abrégé: Brain Tumor Res Treat
Pays: Korea (South)
ID NLM: 101627407
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
29
02
2020
revised:
02
03
2020
accepted:
16
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
ppublish
Résumé
The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted the nationwide questionnaire survey for diverse queries facing to treat patients with brain tumor. As part III of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with brain metastasis and primary central nervous system lymphoma (PCNSL). A web-based survey was sent to all members of the KSNO by email. The survey included 7 questions of brain metastasis and 5 questions of PCNSL, focused on the management strategies in specific situations. All questions were developed by consensus of the Guideline Working Group. In the survey about brain metastasis, respondents preferred surgical resection with adjuvant treatment for patients with a surgically accessible single brain metastatic lesion less than 3 cm in size without extracranial systemic lesions. However, most respondents considered radiosurgery for surgically inaccessible lesions. As the preferred treatment of multiple brain metastases according to the number of brain lesions, respondents tended to choose radiotherapy with increasing number of lesions. Radiosurgery was mostly chosen for the brain metastases of less than or equal to 4. In the survey about PCNSL, a half of respondents choose high-dose methotrexate-based polychemotherapy as the first-line induction therapy for PCNSL. The consolidation and salvage therapy showed a little variation among respondents. For PCNSL patients with cerebrospinal fluid dissemination, intrathecal chemotherapy was most preferred. The survey demonstrates the prevailing clinical practice patterns for patients with brain metastasis and PCNSL among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of brain metastasis and PCNSL.
Sections du résumé
BACKGROUND
BACKGROUND
The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted the nationwide questionnaire survey for diverse queries facing to treat patients with brain tumor. As part III of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with brain metastasis and primary central nervous system lymphoma (PCNSL).
METHODS
METHODS
A web-based survey was sent to all members of the KSNO by email. The survey included 7 questions of brain metastasis and 5 questions of PCNSL, focused on the management strategies in specific situations. All questions were developed by consensus of the Guideline Working Group.
RESULTS
RESULTS
In the survey about brain metastasis, respondents preferred surgical resection with adjuvant treatment for patients with a surgically accessible single brain metastatic lesion less than 3 cm in size without extracranial systemic lesions. However, most respondents considered radiosurgery for surgically inaccessible lesions. As the preferred treatment of multiple brain metastases according to the number of brain lesions, respondents tended to choose radiotherapy with increasing number of lesions. Radiosurgery was mostly chosen for the brain metastases of less than or equal to 4. In the survey about PCNSL, a half of respondents choose high-dose methotrexate-based polychemotherapy as the first-line induction therapy for PCNSL. The consolidation and salvage therapy showed a little variation among respondents. For PCNSL patients with cerebrospinal fluid dissemination, intrathecal chemotherapy was most preferred.
CONCLUSION
CONCLUSIONS
The survey demonstrates the prevailing clinical practice patterns for patients with brain metastasis and PCNSL among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of brain metastasis and PCNSL.
Identifiants
pubmed: 32390350
pii: 8.20
doi: 10.14791/btrt.2020.8.e7
pmc: PMC7221464
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20-28Informations de copyright
Copyright © 2020 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest.
Références
J Clin Oncol. 2003 Jan 15;21(2):266-72
pubmed: 12525518
Handb Clin Neurol. 2018;149:89-112
pubmed: 29307364
J Neurooncol. 1999 Jul;43(3):259-68
pubmed: 10563432
Clin Cancer Res. 2004 Sep 1;10(17):5643-6
pubmed: 15355887
J Clin Oncol. 2003 Mar 15;21(6):1044-9
pubmed: 12637469
Neuro Oncol. 2016 Sep;18(9):1297-303
pubmed: 26951382
Clin Oncol (R Coll Radiol). 2012 Aug;24(6):e81-92
pubmed: 22794327
Ann Neurol. 2002 Feb;51(2):247-52
pubmed: 11835382
J Clin Oncol. 2017 Jul 20;35(21):2410-2418
pubmed: 28640701
J Clin Oncol. 2005 Mar 1;23(7):1507-13
pubmed: 15735126
Br J Cancer. 2011 Oct 25;105(9):1414-8
pubmed: 21915121
J Natl Compr Canc Netw. 2017 Nov;15(11):1331-1345
pubmed: 29118226
J Neurooncol. 2005 Oct;75(1):5-14
pubmed: 16215811
Lancet Oncol. 2015 Jul;16(7):e322-32
pubmed: 26149884
J Cancer Res Clin Oncol. 2017 Sep;143(9):1815-1821
pubmed: 28434043
Lancet Haematol. 2016 May;3(5):e217-27
pubmed: 27132696
Lancet Oncol. 2010 Nov;11(11):1036-47
pubmed: 20970380
JAMA Oncol. 2019 Feb 1;5(2):243-247
pubmed: 30419088
Radiother Oncol. 2017 Mar;122(3):352-361
pubmed: 28104300