Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder.
affective disorders
bipolar disorder
body mass index
diabetes mellitus
glucose metabolism
metabolic syndrome
obesity
prediabetes
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
01
2020
accepted:
30
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Bipolar disorder (BD) is characterized by recurrent episodes of depression and mania and affects up to 2% of the population worldwide. Patients suffering from bipolar disorder have a reduced life expectancy of up to 10 years. The increased mortality might be due to a higher rate of somatic diseases, especially cardiovascular diseases. There is however also evidence for an increased rate of diabetes mellitus in BD, but the reported prevalence rates vary by large. 85 bipolar disorder patients were recruited in the framework of the BiDi study (Prevalence and clinical features of patients with Bipolar Disorder at High Risk for Type 2 Diabetes (T2D), at prediabetic state and with manifest T2D) in Dresden and Würzburg. T2D and prediabetes were diagnosed measuring HBA1c and an oral glucose tolerance test (oGTT), which at present is the gold standard in diagnosing T2D. The BD sample was compared to an age-, sex- and BMI-matched control population (n = 850) from the Study of Health in Pomerania cohort (SHIP Trend Cohort). Patients suffering from BD had a T2D prevalence of 7%, which was not significantly different from the control group (6%). Fasting glucose and impaired glucose tolerance were, contrary to our hypothesis, more often pathological in controls than in BD patients. Nondiabetic and diabetic bipolar patients significantly differed in age, BMI, number of depressive episodes, and disease duration. When controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures to prevent the alarming loss of life years in BD patients.
Identifiants
pubmed: 32390884
doi: 10.3389/fpsyt.2020.00314
pmc: PMC7188755
doi:
Types de publication
Journal Article
Langues
eng
Pagination
314Informations de copyright
Copyright © 2020 Kittel-Schneider, Bury, Leopold, Haack, Bauer, Pfeiffer, Sauer, Pfennig, Völzke, Grabe and Reif.
Références
Lancet Psychiatry. 2019 Sep;6(9):753-765
pubmed: 31320283
Bipolar Disord. 2008 Mar;10(2):342-8
pubmed: 18271914
Bipolar Disord. 2020 Mar;22(2):174-181
pubmed: 31628696
Bipolar Disord. 2009 Sep;11(6):650-6
pubmed: 19689507
Compr Psychiatry. 1980 Jul-Aug;21(4):270-5
pubmed: 7398250
Diabet Med. 2010 Mar;27(3):360-2
pubmed: 20536501
J Affect Disord. 2016 Jan 1;189:240-5
pubmed: 26451510
J Clin Psychiatry. 2006 Jul;67(7):1034-41
pubmed: 16889445
Neuromolecular Med. 2011 Jun;13(2):93-116
pubmed: 21165712
Diabetes Care. 2013 Jan;36 Suppl 1:S11-66
pubmed: 23264422
Schweiz Arch Neurol Psychiatr (1985). 1988;139(2):51-65
pubmed: 2455937
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Acta Psychiatr Scand. 2010 Jun;121(6):437-45
pubmed: 19895620
Diabet Med. 2013 Feb;30(2):e63-9
pubmed: 23072401
Eur Neuropsychopharmacol. 2014 Jun;24(6):890-6
pubmed: 24507017
Neuropsychiatr. 2011;25(1):16-25
pubmed: 21486540
Int J Epidemiol. 2011 Apr;40(2):294-307
pubmed: 20167617
Bipolar Disord. 2007 Aug;9(5):443-52
pubmed: 17680914
Psychiatry Clin Neurosci. 2011 Feb;65(1):47-54
pubmed: 21265935
Gen Hosp Psychiatry. 2005 Sep-Oct;27(5):321-8
pubmed: 16168792
J Psychiatr Res. 2018 Jul;102:34-37
pubmed: 29579625
Dtsch Arztebl Int. 2013 May;110(19):331-7
pubmed: 23762204
Curr Diab Rep. 2016 Jun;16(6):54
pubmed: 27112958
World Psychiatry. 2017 Jun;16(2):163-180
pubmed: 28498599
Transl Psychiatry. 2018 Oct 12;8(1):218
pubmed: 30315151
Psychother Psychosom. 2015;84(3):167-76
pubmed: 25831962
J Affect Disord. 2010 Nov;126(3):366-87
pubmed: 20541810
Acta Psychiatr Scand. 2008 Jul;118(1):4-18
pubmed: 18498432
Dtsch Arztebl Int. 2019 Jun 10;116(23-24):405-411
pubmed: 31366432
Med Klin (Munich). 2006 Sep 15;101(9):730-6
pubmed: 16977398
J Affect Disord. 2016 Sep 15;202:120-3
pubmed: 27262632
J Clin Psychiatry. 2006 Nov;67(11):e16
pubmed: 17201046
J Affect Disord. 2002 Jun;70(1):19-26
pubmed: 12113916
Genomics. 2008 Nov;92(5):265-72
pubmed: 18722519
Diabetes Res Clin Pract. 2014 Feb;103(2):150-60
pubmed: 24300018
Rev Clin Esp. 2010 Oct;210(9):448-53
pubmed: 20667531
Bipolar Disord. 2000 Sep;2(3 Pt 1):191-5
pubmed: 11256686
J Affect Disord. 2019 Feb 15;245:174-179
pubmed: 30391773
Int J Bipolar Disord. 2016 Dec;4(1):13
pubmed: 27389787
JAMA Psychiatry. 2015 Apr;72(4):334-41
pubmed: 25671328
Eur Arch Psychiatry Clin Neurosci. 2019 Jul 13;:
pubmed: 31302731
JAMA. 2000 Nov 22-29;284(20):2606-10
pubmed: 11086367
Diabetes Care. 2009 Jun;32(6):1037-42
pubmed: 19244091
BMJ Open Diabetes Res Care. 2020 Mar;8(1):
pubmed: 32139600
Am J Psychiatry. 1999 Sep;156(9):1417-20
pubmed: 10484954
J Clin Psychiatry. 2001 Jun;62(6):486-91; quiz 492-3
pubmed: 11465534
Ann Clin Psychiatry. 2005 Apr-Jun;17(2):83-93
pubmed: 16075661
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 May;56(5-6):786-94
pubmed: 23703499
Int J Bipolar Disord. 2013 Oct 1;1(1):24
pubmed: 24660139
Nat Genet. 2019 May;51(5):793-803
pubmed: 31043756
Br J Psychiatry. 2015 Jan;206(1):52-7
pubmed: 25323142
Diabetes Care. 2010 Jan;33 Suppl 1:S62-9
pubmed: 20042775
J Affect Disord. 2012 Feb;136(3):599-603
pubmed: 22119084
Nature. 2006 Dec 14;444(7121):840-6
pubmed: 17167471
J Nerv Ment Dis. 1986 Dec;174(12):736-42
pubmed: 3783141
J Hum Genet. 2014 Jan;59(1):54-6
pubmed: 24196380
JAMA Psychiatry. 2013 Oct;70(10):1091-9
pubmed: 23986353
Pharmacoepidemiol Drug Saf. 2009 Sep;18(9):791-9
pubmed: 19526626
Psychosom Med. 2006 Sep-Oct;68(5):684-91
pubmed: 17012521
Br J Psychiatry. 2017 Sep;211(3):175-181
pubmed: 28684403
J Psychosom Res. 2002 Oct;53(4):925-33
pubmed: 12377305
Dtsch Arztebl Int. 2015 Mar 13;112(11):185-92
pubmed: 25837860
J Clin Psychiatry. 2006 Jul;67(7):1055-61
pubmed: 16889448
Psychiatry Res. 1997 Dec 5;73(3):159-71
pubmed: 9481807
J Clin Psychiatry. 2003 Dec;64(12):1426-35
pubmed: 14728103
Bipolar Disord. 2003 Jun;5(3):189-202
pubmed: 12780873
World Psychiatry. 2016 Jun;15(2):166-74
pubmed: 27265707
Nord J Psychiatry. 2016 Nov;70(8):611-20
pubmed: 27299922
Sci Rep. 2019 Dec 18;9(1):19342
pubmed: 31852999
Nord J Psychiatry. 2018 Oct;72(7):455-461
pubmed: 30513230
JAMA Psychiatry. 2020 Jan 8;:
pubmed: 31913414