Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses.
Animals
Calcium Signaling
/ drug effects
Cell Degranulation
/ drug effects
Cell Line, Tumor
Coumarins
/ administration & dosage
Disease Models, Animal
Edema
/ drug therapy
Female
Humans
Male
Mast Cells
/ drug effects
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Docking Simulation
Nerve Tissue Proteins
/ antagonists & inhibitors
Phytotherapy
/ methods
Plant Extracts
/ administration & dosage
Rats
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Receptors, Neuropeptide
/ antagonists & inhibitors
Tissue Donors
Treatment Outcome
MAS-related G-protein coupled receptor-X2
MrgprB2
mast cells
osthole
pseudo-allergic reactions
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
01
2020
accepted:
30
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic and amphipathic properties. Interestingly, MRGPRX2 ligands include certain FDA-approved drugs, antimicrobial peptides, and neuropeptides. Consequently, this receptor has been implicated in causing mast cell-dependent pseudo-allergic reactions to these drugs and chronic inflammation associated with asthma, urticaria and rosacea in humans. In the current study we examined the role of osthole, a natural plant coumarin, in regulating mast cell responses when activated by the MRGPRX2 ligands, including compound 48/80, the neuropeptide substance P, and the cathelicidin LL-37. We demonstrate that osthole attenuates both the early (Ca
Identifiants
pubmed: 32391014
doi: 10.3389/fimmu.2020.00703
pmc: PMC7194083
doi:
Substances chimiques
Coumarins
0
MRGPRX2 protein, human
0
Mrgprx2 protein, mouse
0
Nerve Tissue Proteins
0
Plant Extracts
0
Receptors, G-Protein-Coupled
0
Receptors, Neuropeptide
0
osthol
XH1TI1759C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
703Subventions
Organisme : NCI NIH HHS
ID : K22 CA188149
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR067996
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL121073
Pays : United States
Informations de copyright
Copyright © 2020 Callahan, Kammala, Syed, Yang, Occhiuto, Nellutla, Chumanevich, Oskeritzian, Das and Subramanian.
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