Genome-Wide Association Study Reveals Novel Marker-Trait Associations (MTAs) Governing the Localization of Fe and Zn in the Rice Grain.
Fe
GWAS
Zn
biofortification
brown rice
donors
milled rice
rice
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
09
2019
accepted:
24
02
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Micronutrient malnutrition due to Fe and Zn, affects around two billion people globally particularly in the developing countries. More than 90% of the Asian population is dependent on rice-based diets, which is low in these micronutrients. In the present study, a set of 192 Indian rice germplasm accessions, grown at two locations, were evaluated for Fe and Zn in brown rice (BR) and milled rice (MR). A significant variation was observed in the rice germplasm for these micronutrients. The grain Fe concentration was in the range of 6.2-23.1 ppm in BR and 0.8-12.3 ppm in MR, while grain Zn concentration was found to be in the range of 11.0-47.0 ppm and 8.2-40.8 ppm in the BR and MR, respectively. Grain Fe exhibited maximum loss upon milling with a mean retention of 24.9% in MR, while Zn showed a greater mean retention of 74.2% in MR. A genome-wide association study (GWAS) was carried out implementing the FarmCPU model to control the population structure and kinship, and resulted in the identification of 29 marker-trait associations (MTAs) with significant associations for traits viz. FeBR (6 MTAs), FeMR (7 MTAs), ZnBR (11 MTAs), and ZnMR (5 MTAs), which could explain the phenotypic variance from 2.1 to as high as 53.3%. The MTAs governing the correlated traits showed co-localization, signifying the possibility of their simultaneous improvement. The robust MTAs identified in the study could be valuable resource for enhancing Fe and Zn concentration in the rice grain and addressing the problem of Fe and Zn malnutrition among rice consumers.
Identifiants
pubmed: 32391041
doi: 10.3389/fgene.2020.00213
pmc: PMC7188789
doi:
Types de publication
Journal Article
Langues
eng
Pagination
213Informations de copyright
Copyright © 2020 Bollinedi, Yadav, Vinod, Gopala Krishnan, Bhowmick, Nagarajan, Neeraja, Ellur and Singh.
Références
Biotechnol Adv. 2013 Dec;31(8):1624-33
pubmed: 23973806
PLoS Comput Biol. 2017 Jan 31;13(1):e1005357
pubmed: 28141824
J Agric Food Chem. 2015 Dec 23;63(50):10885-92
pubmed: 26641542
Front Plant Sci. 2016 Jun 07;7:787
pubmed: 27375646
PLoS One. 2014 Feb 25;9(2):e89685
pubmed: 24586963
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):22014-9
pubmed: 20080803
Food Nutr Bull. 2018 Jun;39(2):246-259
pubmed: 29281918
Bioinformatics. 2012 Sep 15;28(18):2397-9
pubmed: 22796960
Proc Nutr Soc. 2003 May;62(2):403-11
pubmed: 14506888
J Nutr. 2001 Feb;131(2S-2):697S-700S; discussion 700S-701S
pubmed: 11160600
PLoS Genet. 2016 Feb 01;12(2):e1005767
pubmed: 26828793
Plant J. 2005 Dec;44(6):1054-64
pubmed: 16359397
J Sci Food Agric. 2013 Jan;93(2):254-61
pubmed: 22740351
Front Plant Sci. 2018 Sep 05;9:1311
pubmed: 30233634
Plant Biotechnol J. 2009 Sep;7(7):631-44
pubmed: 19702755
PLoS One. 2014 Oct 31;9(10):e111508
pubmed: 25360796
PLoS One. 2019 Mar 6;14(3):e0212925
pubmed: 30840677
Mol Ecol. 2005 Jul;14(8):2611-20
pubmed: 15969739
Plant Physiol. 2003 Sep;133(1):126-34
pubmed: 12970480
BMC Plant Biol. 2020 Feb 4;20(1):57
pubmed: 32019504
Plant Cell. 2003 Jun;15(6):1263-80
pubmed: 12782722
PLoS One. 2019 Feb 22;14(2):e0208217
pubmed: 30794545
Front Plant Sci. 2018 Sep 20;9:1347
pubmed: 30294335
PLoS One. 2019 Jul 8;14(7):e0219274
pubmed: 31283792
J Integr Plant Biol. 2009 Jan;51(1):84-92
pubmed: 19166498
Lancet. 2008 Jan 19;371(9608):243-60
pubmed: 18207566
Gene. 2012 Oct 25;508(2):233-40
pubmed: 22964359
Plant Physiol. 1999 Mar;119(3):1107-14
pubmed: 10069850
Am J Trop Med Hyg. 2004 Aug;71(2 Suppl):55-63
pubmed: 15331819
Bioinformatics. 2007 Oct 1;23(19):2633-5
pubmed: 17586829
Front Plant Sci. 2018 Jul 09;9:966
pubmed: 30038634
Nat Genet. 2010 Nov;42(11):961-7
pubmed: 20972439
Planta. 2016 Oct;244(4):819-30
pubmed: 27198135
Nutrients. 2013 Aug 13;5(8):3184-211
pubmed: 23945676
Heredity (Edinb). 2017 Sep;119(3):174-184
pubmed: 28590463
Sci Rep. 2016 Jan 25;6:19792
pubmed: 26806528
Nat Biotechnol. 1999 Mar;17(3):282-6
pubmed: 10096297
PLoS One. 2011;6(9):e24476
pubmed: 21915334
PLoS One. 2012;7(3):e32982
pubmed: 22427922
Sci Rep. 2015 Jun 26;5:11600
pubmed: 26111882
BMC Genomics. 2019 Jul 29;20(1):618
pubmed: 31357925
Glob Food Sec. 2017 Mar;12:49-58
pubmed: 28580239
Food Res Int. 2015 Aug;74:131-139
pubmed: 28411977
Genetics. 2000 Jun;155(2):945-59
pubmed: 10835412
Sci Rep. 2012;2:543
pubmed: 22848789
BMC Genomics. 2017 Nov 7;18(1):849
pubmed: 29115920
Plant Cell. 2018 Nov;30(11):2720-2740
pubmed: 30373760
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Plant J. 2015 Oct;84(2):374-84
pubmed: 26332571
Front Plant Sci. 2016 Nov 29;7:1801
pubmed: 27965699
Heredity (Edinb). 2018 Mar;120(3):208-218
pubmed: 29234158
Am J Clin Nutr. 1991 Feb;53(2):403-12
pubmed: 1989405
Food Nutr Bull. 2004 Mar;25(1 Suppl 2):S99-203
pubmed: 18046856
Nucleic Acids Res. 1980 Oct 10;8(19):4321-5
pubmed: 7433111