Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells.
cancer stem cell
chimeric antigen receptor T cell
chimeric antigen receptor T cell production
chimeric antigen receptor T cell signaling
chimeric antigen receptor generations
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
12
2019
accepted:
16
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
The term cancer stem cell (CSC) starts 25 years ago with the evidence that CSC is a subpopulation of tumor cells that have renewal ability and can differentiate into several distinct linages. Therefore, CSCs play crucial role in the initiation and the maintenance of cancer. Moreover, it has been proposed throughout several studies that CSCs are behind the failure of the conventional chemo-/radiotherapy as well as cancer recurrence due to their ability to resist the therapy and their ability to re-regenerate. Thus, the need for targeted therapy to eliminate CSCs is crucial; for that reason, chimeric antigen receptor (CAR) T cells has currently been in use with high rate of success in leukemia and, to some degree, in patients with solid tumors. This review outlines the most common CSC populations and their common markers, in particular CD133, CD90, EpCAM, CD44, ALDH, and EGFR
Identifiants
pubmed: 32391048
doi: 10.3389/fgene.2020.00312
pmc: PMC7188929
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
312Informations de copyright
Copyright © 2020 Alhabbab.
Références
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Science. 2018 Sep 28;361(6409):
pubmed: 30262472
Oncol Lett. 2014 May;7(5):1544-1548
pubmed: 24765173
Cancers (Basel). 2019 Mar 11;11(3):
pubmed: 30862050
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Trends Biochem Sci. 2011 Jun;36(6):320-8
pubmed: 21531565
PLoS One. 2014 Dec 23;9(12):e115507
pubmed: 25536077
Cell Stem Cell. 2015 Sep 3;17(3):260-71
pubmed: 26340526
Am J Cancer Res. 2017 Mar 01;7(3):503-517
pubmed: 28401007
BMC Immunol. 2015 Jan 31;16:1
pubmed: 25636521
Cancer Immunol Immunother. 2011 Oct;60(10):1447-60
pubmed: 21647691
ACS Appl Mater Interfaces. 2016 Jul 20;8(28):17793-804
pubmed: 27348241
Int J Biol Markers. 2015 Feb 24;30(1):e49-55
pubmed: 24832177
J Exp Med. 1982 Apr 1;155(4):1063-74
pubmed: 6460831
Cell. 2008 May 16;133(4):704-15
pubmed: 18485877
Cancer Cell. 2011 Dec 13;20(6):810-7
pubmed: 22137795
J Clin Invest. 2016 Oct 3;126(10):3814-3826
pubmed: 27571406
Front Cell Dev Biol. 2019 Apr 26;7:66
pubmed: 31080802
Jpn J Cancer Res. 1990 Aug;81(8):773-9
pubmed: 2168866
PLoS One. 2017 Mar 1;12(3):e0171460
pubmed: 28248963
Cancer Res. 1995 Dec 1;55(23):5536-9
pubmed: 7585629
Cell Death Dis. 2018 Feb 7;9(2):177
pubmed: 29415996
Front Oncol. 2019 Feb 11;9:51
pubmed: 30805309
Breast Cancer Res. 2008;10(3):R53
pubmed: 18559090
Front Oncol. 2017 May 05;7:80
pubmed: 28529925
J Exp Med. 2005 Oct 3;202(7):907-12
pubmed: 16203864
J Immunother. 2012 Feb-Mar;35(2):205-13
pubmed: 22306909
Cancers (Basel). 2019 Jul 09;11(7):
pubmed: 31324052
Oncogene. 2013 May 23;32(21):2670-81
pubmed: 22797070
Medicine (Baltimore). 2016 Sep;95(39):e4909
pubmed: 27684826
J Immunol. 2004 May 1;172(9):5149-53
pubmed: 15100250
Cancer Cell. 2018 Apr 9;33(4):547-562
pubmed: 29634943
Neuro Oncol. 2010 Nov;12(11):1113-25
pubmed: 20667896
Onco Targets Ther. 2018 Oct 16;11:7053-7059
pubmed: 30410362
Mol Cancer Res. 2009 Mar;7(3):330-8
pubmed: 19276181
Pharmacol Ther. 2016 Apr;160:145-58
pubmed: 26899500
Sci Transl Med. 2014 Feb 19;6(224):224ra25
pubmed: 24553386
Expert Opin Ther Targets. 2012 Oct;16(10):1041-54
pubmed: 22877147
N Engl J Med. 2011 Aug 25;365(8):725-33
pubmed: 21830940
Blood. 2007 Oct 1;110(7):2659-66
pubmed: 17609428
Cell Stem Cell. 2014 Mar 6;14(3):342-56
pubmed: 24607406
Biochim Biophys Acta. 2009 May;1793(5):921-3
pubmed: 19007822
N Engl J Med. 2016 Dec 29;375(26):2561-9
pubmed: 28029927
Immunology. 2018 Mar;153(3):304-314
pubmed: 29150846
Nat Rev Drug Discov. 2017 Sep 29;16(10):669
pubmed: 28959944
Carcinogenesis. 2014 Dec;35(12):2771-7
pubmed: 25269803
Cancer Res. 1996 Nov 1;56(21):5079-86
pubmed: 8895767
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63
pubmed: 17548814
Blood. 2010 Nov 11;116(19):3875-86
pubmed: 20631379
Oncoimmunology. 2018 Feb 22;7(5):e1426518
pubmed: 29721395
Cancer Res. 2007 Nov 15;67(22):10831-9
pubmed: 18006828
Carcinogenesis. 2010 Nov;31(11):1913-21
pubmed: 20837599
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16642-7
pubmed: 23012408
Blood. 2017 Jun 22;129(25):3322-3331
pubmed: 28408462
Transl Lung Cancer Res. 2016 Jun;5(3):272-9
pubmed: 27413709
Biochem Biophys Res Commun. 1987 Dec 31;149(3):960-8
pubmed: 3122749
FASEB J. 2006 Jun;20(8):1045-54
pubmed: 16770003
Exp Cell Res. 2003 Mar 10;284(1):2-13
pubmed: 12648462
Int J Biol Markers. 2013 Dec 17;28(4):e357-64
pubmed: 24338721
J Hematol Oncol. 2017 Oct 23;10(1):166
pubmed: 29058636
J Exp Med. 1994 Jul 1;180(1):211-22
pubmed: 7516408
N Engl J Med. 2018 Jul 5;379(1):64-73
pubmed: 29972754
J Immunol Res. 2018 Apr 17;2018:2386187
pubmed: 29850622
J Exp Med. 2011 Mar 14;208(3):491-503
pubmed: 21383056
N Engl J Med. 2014 Oct 16;371(16):1507-17
pubmed: 25317870
PLoS One. 2013;8(3):e57020
pubmed: 23469181
Lancet. 2015 Feb 7;385(9967):517-528
pubmed: 25319501
Cancer Res. 2014 Apr 15;74(8):2152-9
pubmed: 24525740
Nat Immun. 1993 Jul-Oct;12(4-5):194-208
pubmed: 8257826
J Cancer. 2015 Jul 16;6(9):866-76
pubmed: 26284138
Stem Cells Transl Med. 2019 Jan;8(1):75-81
pubmed: 30328686
Gastroenterology. 2009 Mar;136(3):1012-24
pubmed: 19150350
Eur J Cancer. 2014 Feb;50(3):649-55
pubmed: 24333096
Cell. 2016 Mar 24;165(1):45-60
pubmed: 27015306
Cancer Res. 2013 Apr 1;73(7):2322-32
pubmed: 23382045
Cancer Immunol Immunother. 2010 Oct;59(10):1521-30
pubmed: 20563721
Cell Stem Cell. 2010 May 7;6(5):421-32
pubmed: 20452317
Int J Oncol. 2009 May;34(5):1201-7
pubmed: 19360333
Cancer Res. 2011 Jun 1;71(11):3991-4001
pubmed: 21498635
Nat Immunol. 2015 Sep;16(9):961-9
pubmed: 26237552
Cancer Cell. 2005 Nov;8(5):369-80
pubmed: 16286245
J Immunol. 1997 Nov 15;159(10):4815-22
pubmed: 9366406
Respirology. 2013 Jul;18(5):757-64
pubmed: 23586700
Cytotherapy. 2009;11(7):923-35
pubmed: 19903104
Cancer J. 2014 Mar-Apr;20(2):119-22
pubmed: 24667956
Sci Transl Med. 2011 Aug 10;3(95):95ra73
pubmed: 21832238
Oncoimmunology. 2017 Oct 11;7(2):e1380765
pubmed: 29416940
Cancer Med. 2014 Apr;3(2):362-75
pubmed: 24515916
J Cancer. 2017 Feb 11;8(4):537-554
pubmed: 28367234
Cell Stem Cell. 2019 Jan 3;24(1):41-53
pubmed: 30609398
Oncotarget. 2016 Mar 8;7(10):11223-37
pubmed: 26849232
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8
pubmed: 12629218
J Surg Oncol. 2014 Nov;110(6):745-51
pubmed: 24975268
Nat Biotechnol. 2018 Apr;36(4):346-351
pubmed: 29505028
Stem Cells. 2011 Jan;29(1):32-45
pubmed: 21280157
Clin Exp Immunol. 2010 Aug;161(2):290-7
pubmed: 20491785
Cancer Res. 2003 Sep 15;63(18):5821-8
pubmed: 14522905
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1010-6
pubmed: 24657266
Front Immunol. 2013 Dec 25;4:490
pubmed: 24400010
Blood. 2013 May 2;121(18):3709-13
pubmed: 23479569
J Clin Invest. 1998 Jan 15;101(2):429-41
pubmed: 9435316
Front Immunol. 2017 Jun 09;8:654
pubmed: 28649246
Front Immunol. 2018 Aug 09;9:1859
pubmed: 30140269
Toxins (Basel). 2016 May 28;8(6):
pubmed: 27240402
Nature. 2007 Jan 4;445(7123):111-5
pubmed: 17122771
Anticancer Res. 2010 Apr;30(4):1201-3
pubmed: 20530428
Nat Biotechnol. 2002 Jan;20(1):70-5
pubmed: 11753365
J Immunol. 2017 Oct 1;199(7):2191-2193
pubmed: 28923980
Cancer Res. 2014 Jan 1;74(1):104-18
pubmed: 24197130
Blood. 2014 Jul 17;124(3):385-92
pubmed: 24859366
Sci Transl Med. 2013 Mar 20;5(177):177ra38
pubmed: 23515080
Nat Cell Biol. 2015 Feb;17(2):170-82
pubmed: 25580734
Nat Cell Biol. 2014 Nov;16(11):1105-17
pubmed: 25266422
Mol Cell Proteomics. 2014 Oct;13(10):2618-31
pubmed: 24997998
Lancet. 1994 Nov 26;344(8935):1470-2
pubmed: 7526103
Proc Natl Acad Sci U S A. 1989 Dec;86(24):10024-8
pubmed: 2513569
Nat Rev Genet. 2003 May;4(5):346-58
pubmed: 12728277
Nature. 2017 Dec;552(7685):S67-S69
pubmed: 32094671
Nat Med. 2009 Sep;15(9):1010-2
pubmed: 19734877
Nat Med. 2017 Oct 6;23(10):1124-1134
pubmed: 28985214
Oncotarget. 2017 Feb 21;8(8):13545-13559
pubmed: 28088790
Ann Oncol. 1997 Dec;8(12):1197-206
pubmed: 9496384
Eur J Immunol. 2013 Oct;43(10):2756-64
pubmed: 23913266
Nat Clin Pract Oncol. 2006 Dec;3(12):668-81
pubmed: 17139318
J Immunol. 2013 Mar 1;190(5):2381-90
pubmed: 23345327
Cancer Sci. 2010 Oct;101(10):2145-55
pubmed: 20707805
Cell Stress. 2019 May 21;3(6):165-180
pubmed: 31225512
Nat Med. 1997 Jul;3(7):730-7
pubmed: 9212098
Cancer Cell. 2012 Mar 20;21(3):309-22
pubmed: 22439926
Clin Cancer Res. 2010 Feb 1;16(3):876-87
pubmed: 20103682
Nat Commun. 2016 Jul 27;7:12320
pubmed: 27460500
Stem Cell Reports. 2013 Dec 27;2(1):78-91
pubmed: 24511467
Mol Ther Methods Clin Dev. 2016 Dec 31;4:92-101
pubmed: 28344995
BMC Cancer. 2016 Mar 16;16:228
pubmed: 26984381
Science. 2013 Aug 23;341(6148):1233151
pubmed: 23845947
Immunology. 2018 Jan;153(1):42-50
pubmed: 28771705
PLoS One. 2013 Oct 08;8(10):e76830
pubmed: 24116172
Immunity. 2010 Jan 29;32(1):104-15
pubmed: 20079666
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7536-E7544
pubmed: 28827353
Mol Ther. 2010 Apr;18(4):843-51
pubmed: 20179677
J Immunother. 2019 May;42(4):126-135
pubmed: 30882547
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4120-5
pubmed: 12646700
J Immunol. 2009 Mar 15;182(6):3530-9
pubmed: 19265131
Biol Blood Marrow Transplant. 2018 Jun;24(6):1152-1162
pubmed: 29505821
Cancer Res. 1995 May 1;55(9):1831-5
pubmed: 7537174
Oncogenesis. 2017 May 29;6(5):e342
pubmed: 28553931
Front Immunol. 2018 Nov 08;9:2517
pubmed: 30467503
Nat Immunol. 2017 Jan;18(1):86-95
pubmed: 27869819
Cell Rep. 2017 Oct 31;21(5):1399-1410
pubmed: 29091775
Prostate. 2014 May;74(6):602-17
pubmed: 24615685
Mol Cancer. 2011 Sep 14;10:112
pubmed: 21917149
J Clin Invest. 2016 Jun 1;126(6):2123-38
pubmed: 27111235
Expert Opin Ther Targets. 2009 Jul;13(7):823-37
pubmed: 19530986
Science. 2015 Jan 16;347(6219):226-9
pubmed: 25593170
Nature. 2004 Nov 18;432(7015):396-401
pubmed: 15549107
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5807-10
pubmed: 22902654
Cancer Res. 2018 Feb 15;78(4):1031-1043
pubmed: 29222400
J Hepatol. 2010 Jun;52(6):872-9
pubmed: 20395004
Sci STKE. 2006 Jan 31;2006(320):re1
pubmed: 16449667
Cancer Res. 2010 Jun 15;70(12):5163-73
pubmed: 20516116
Cell. 2010 Sep 17;142(6):847-56
pubmed: 20850008
FASEB J. 2008 Oct;22(10):3696-705
pubmed: 18614581
Cell Stem Cell. 2007 Nov;1(5):555-67
pubmed: 18371393
Tumour Biol. 2016 Sep;37(9):11611-11622
pubmed: 27337957
EMBO Mol Med. 2017 Sep;9(9):1183-1197
pubmed: 28765140
Exp Hematol. 2000 Jun;28(6):660-71
pubmed: 10880752
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11008-13
pubmed: 17576927
J Hematol Oncol. 2017 Jan 5;10(1):4
pubmed: 28057014
Cancer Sci. 2003 Jan;94(1):50-6
pubmed: 12708474
Oncoimmunology. 2018 May 7;7(7):e1440169
pubmed: 29900044
Nat Med. 2018 Jan;24(1):20-28
pubmed: 29155426
Front Surg. 2016 Apr 15;3:21
pubmed: 27148537
Nat Rev Cancer. 2009 Feb;9(2):143; author reply 143
pubmed: 19132011
PLoS One. 2015 Jun 18;10(6):e0130519
pubmed: 26086074
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2965-9
pubmed: 1557402
PLoS One. 2014 Oct 03;9(10):e109427
pubmed: 25279468
Transfusion. 2018 Jun;58(6):1414-1420
pubmed: 29536556
Cancer Res. 1995 Jul 15;55(14):3140-8
pubmed: 7606735
J Neurooncol. 2012 Feb;106(3):493-504
pubmed: 21928115
Science. 2013 Aug 23;341(6148):1233158
pubmed: 23845948
Cancer Immunol Immunother. 2008 Jul;57(7):1053-66
pubmed: 18188563
Toxicol Pathol. 2018 Feb;46(2):131-146
pubmed: 29471776
Clin Cancer Res. 2015 Jul 15;21(14):3149-59
pubmed: 25850950
Sci Transl Med. 2016 Sep 7;8(355):355ra116
pubmed: 27605551
PLoS One. 2016 May 06;11(5):e0155230
pubmed: 27153109
Stem Cells Int. 2016;2016:2087204
pubmed: 27200096
EMBO J. 1999 Apr 1;18(7):1832-44
pubmed: 10202147
J Immunol. 2005 Apr 1;174(7):3992-8
pubmed: 15778356
Hum Genomics. 2011 May;5(4):283-303
pubmed: 21712190
Mol Cancer. 2013 Aug 16;12(1):94
pubmed: 23947765
Cell Stem Cell. 2009 Jul 2;5(1):31-42
pubmed: 19570512
Gene Ther. 2013 Oct;20(10):970-8
pubmed: 23636245
Nat Commun. 2018 May 15;9(1):1908
pubmed: 29765039
Cancer Res. 2014 Oct 15;74(20):5746-57
pubmed: 25164008
J Clin Invest. 2011 Mar;121(3):1064-74
pubmed: 21393860
Protein Cell. 2018 Jun;9(6):516-526
pubmed: 28290053
Cancer Res. 2005 Dec 1;65(23):10946-51
pubmed: 16322242
Mol Ther Oncolytics. 2016 Apr 20;3:16011
pubmed: 27626062
Nat Med. 2019 Sep;25(9):1341-1355
pubmed: 31501612
Cytotherapy. 2017 Apr;19(4):473-485
pubmed: 28188072
Cancer Immunol Immunother. 2011 Aug;60(8):1075-84
pubmed: 21519826
Nat Med. 2018 Mar;24(3):352-359
pubmed: 29400710
J Immunol. 2015 Oct 15;195(8):4010-9
pubmed: 26363055
Stem Cells. 2016 Aug;34(8):2026-39
pubmed: 27145382
Cancer Res. 2007 May 1;67(9):4010-5
pubmed: 17483311
Clin Cancer Res. 2010 Feb 1;16(3):800-13
pubmed: 20103663
Blood. 2013 Jun 27;121(26):5154-7
pubmed: 23678006
Eur J Immunol. 2014 Jun;44(6):1582-92
pubmed: 24777896
Stem Cells. 2014 Jul;32(7):1746-58
pubmed: 24737733
Mol Cell Biol. 2005 Jun;25(12):4924-33
pubmed: 15923611
Crit Rev Immunol. 2012;32(6):463-88
pubmed: 23428224
Hum Gene Ther. 2019 Apr;30(4):402-412
pubmed: 30693795
Front Immunol. 2017 Feb 03;8:45
pubmed: 28217126
JCI Insight. 2018 Sep 20;3(18):
pubmed: 30232281
Diagn Pathol. 2014 Apr 08;9:79
pubmed: 24708709
Clin Cancer Res. 2011 Oct 1;17(19):6174-84
pubmed: 21856769
Int J Clin Exp Pathol. 2015 May 01;8(5):5105-12
pubmed: 26191205
Nat Rev Cancer. 2008 Oct;8(10):755-68
pubmed: 18784658
Immunology. 2002 Apr;105(4):369-74
pubmed: 11985657
Curr Treat Options Oncol. 2018 Mar 20;19(4):20
pubmed: 29556842
J Immunol. 1998 Sep 15;161(6):2791-7
pubmed: 9743337
J Neuroimmunol. 2013 Dec 15;265(1-2):106-16
pubmed: 24090655
Mol Cell Proteomics. 2012 Jun;11(6):M111.010744
pubmed: 22203689
Nature. 2010 Sep 16;467(7313):318-22
pubmed: 20844535
Blood. 2017 Nov 23;130(21):2317-2325
pubmed: 28935694
Br J Cancer. 2014 Jul 15;111(2):365-74
pubmed: 24921913
PLoS Comput Biol. 2013;9(3):e1003004
pubmed: 23555234
Nat Rev Drug Discov. 2020 Mar;19(3):169-184
pubmed: 31492944
Virchows Arch. 1996 Nov;429(4-5):191-5
pubmed: 8972753
Cancer J. 2014 Mar-Apr;20(2):141-4
pubmed: 24667960
Nat Rev Clin Oncol. 2019 Jun;16(6):372-385
pubmed: 30837712
Cancer Res. 2004 Aug 15;64(16):5818-24
pubmed: 15313925
Mol Ther. 2013 Apr;21(4):904-12
pubmed: 23423337
Cancer Res. 2014 Feb 15;74(4):1238-49
pubmed: 24366881
Cytokine. 2019 May;117:30-40
pubmed: 30784898
Oncogene. 2012 Feb 9;31(6):671-82
pubmed: 21743497
Front Immunol. 2018 Nov 15;9:2618
pubmed: 30524423
Biofactors. 2009 May-Jun;35(3):258-65
pubmed: 19422052
Clin Chem. 2013 Jan;59(1):168-79
pubmed: 23220226
Oncoimmunology. 2019 Nov 7;9(1):1683345
pubmed: 32002293
Clin Cancer Res. 2013 Oct 15;19(20):5636-46
pubmed: 23873688
Sci Transl Med. 2015 May 27;7(289):289ra82
pubmed: 26019218
Mol Ther. 2005 Nov;12(5):933-41
pubmed: 15979412
Eur J Cardiothorac Surg. 2010 May;37(5):1191-7
pubmed: 20137969
Science. 2012 Aug 10;337(6095):730-5
pubmed: 22855427
Nat Rev Immunol. 2003 Dec;3(12):939-51
pubmed: 14647476
PLoS One. 2015 Jul 14;10(7):e0132479
pubmed: 26172046
Stem Cells Dev. 2007 Oct;16(5):837-47
pubmed: 17999604
Cancer Lett. 2015 Apr 10;359(2):155-64
pubmed: 25644088
N Engl J Med. 2019 Jan 3;380(1):45-56
pubmed: 30501490
Genes Dev. 2006 Jul 1;20(13):1715-20
pubmed: 16818603
Clin Cancer Res. 2018 Jan 1;24(1):95-105
pubmed: 29061641
Front Immunol. 2018 Jun 19;9:1412
pubmed: 29971070
J Clin Invest. 2013 May;123(5):1911-8
pubmed: 23635789
Cell Stem Cell. 2007 Sep 13;1(3):313-23
pubmed: 18371365
Cancer Immunol Immunother. 2016 Sep;65(9):1085-97
pubmed: 27439500
PLoS One. 2010 Nov 19;5(11):e14062
pubmed: 21124918
Cell Stem Cell. 2010 Jun 4;6(6):603-15
pubmed: 20569697
Oncotarget. 2017 Feb 7;8(6):9488-9499
pubmed: 28055955
PLoS One. 2010 Apr 21;5(4):e10277
pubmed: 20422001
PLoS One. 2013 Apr 09;8(4):e61338
pubmed: 23585892
Nature. 1994 Feb 17;367(6464):645-8
pubmed: 7509044
Front Immunol. 2018 Jun 26;9:1409
pubmed: 29997614
Cancer Sci. 2016 Jan;107(1):12-7
pubmed: 26440127
Oncotarget. 2015 Apr 20;6(11):8947-59
pubmed: 25860927
Jpn J Cancer Res. 1998 Oct;89(10):1033-40
pubmed: 9849582
Cancer Lett. 2015 Dec 1;369(1):50-7
pubmed: 26319899
Hum Gene Ther Methods. 2013 Oct;24(5):310-20
pubmed: 23931270
Neuro Oncol. 2016 Feb;18(2):153-9
pubmed: 26264894
PLoS One. 2010 Jul 16;5(7):e11590
pubmed: 20661281
PLoS One. 2012;7(5):e37204
pubmed: 22623992
PLoS One. 2013;8(1):e53510
pubmed: 23308242
Hum Gene Ther. 2007 Aug;18(8):712-25
pubmed: 17685852
Biochem Pharmacol. 2014 Sep 15;91(2):135-43
pubmed: 24950467
Immunol Today. 2000 Nov;21(11):584-91
pubmed: 11094263
Oncotarget. 2015 May 20;6(14):12637-53
pubmed: 25868979
Blood. 2016 Jan 7;127(1):122-31
pubmed: 26531164
Br J Cancer. 2019 Jan;120(1):26-37
pubmed: 30413825
PLoS One. 2016 Nov 3;11(11):e0165718
pubmed: 27812180
Br J Cancer. 2018 Dec;119(12):1495-1507
pubmed: 30482914
Nat Rev Immunol. 2001 Dec;1(3):220-8
pubmed: 11905831
Gut. 2010 Jul;59(7):953-62
pubmed: 20442200
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83
pubmed: 14645703
World J Stem Cells. 2015 Oct 26;7(9):1185-201
pubmed: 26516409
J Neurooncol. 2007 Jun;83(2):121-31
pubmed: 17077937
Blood Cancer J. 2016 Aug 12;6(8):e458
pubmed: 27518241
Biomark Res. 2017 Jun 24;5:22
pubmed: 28652918
Front Immunol. 2014 Jun 19;5:269
pubmed: 24995006
Sci Transl Med. 2017 Jul 19;9(399):
pubmed: 28724573
J Cancer. 2013;4(1):12-24
pubmed: 23386901
Cell Rep. 2017 Oct 3;21(1):17-26
pubmed: 28978471
Science. 2001 Oct 19;294(5542):605-9
pubmed: 11567106
J Immunol. 1996 Feb 1;156(3):907-15
pubmed: 8558016
Breast Cancer Res. 2008;10(2):R25
pubmed: 18366788
Front Immunol. 2015 Dec 02;6:576
pubmed: 26697005
Nature. 2001 Nov 1;414(6859):105-11
pubmed: 11689955
PLoS One. 2017 Feb 27;12(2):e0172791
pubmed: 28241049
Cancers (Basel). 2019 Mar 05;11(3):
pubmed: 30841635
Blood. 2003 Jul 1;102(1):200-6
pubmed: 12623838
Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4
pubmed: 28089910
J Gene Med. 2013 Feb;15(2):78-82
pubmed: 23322669
Expert Opin Drug Discov. 2017 Oct;12(10):1053-1065
pubmed: 28748730
J Immunol. 2012 Feb 1;188(3):1442-50
pubmed: 22210915
J Immunol. 2014 Jan 1;192(1):523-32
pubmed: 24277698
Int J Biochem Cell Biol. 2014 Jun;51:23-8
pubmed: 24681003
Mol Vis. 2010 May 11;16:828-42
pubmed: 20461151
Cancer Discov. 2014 Aug;4(8):956-71
pubmed: 24893890
Anat Cell Biol. 2015 Mar;48(1):44-53
pubmed: 25806121
Clin Cancer Res. 2017 Feb 1;23(3):615-617
pubmed: 27872101
Cancer Res. 2011 Dec 15;71(24):7587-96
pubmed: 22001862
Nature. 2017 May 11;545(7653):187-192
pubmed: 28355176
Cancer Res. 2007 Aug 1;67(15):7450-7
pubmed: 17671215
Adv Exp Med Biol. 2018;1089:97-113
pubmed: 30255300
Int J Cancer. 2008 Feb 15;122(4):761-8
pubmed: 17955491
Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):697-720
pubmed: 18611112
J Transl Med. 2017 Mar 16;15(1):59
pubmed: 28298232
Oncogene. 2009 Jan 15;28(2):209-18
pubmed: 18836486
Sci China Life Sci. 2018 Nov;61(11):1320-1332
pubmed: 30414005
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12425-30
pubmed: 21746895
Int J Nanomedicine. 2015 Sep 10;10(Spec Iss):251-60
pubmed: 26425092
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Oncotarget. 2016 Nov 29;7(48):80046-80058
pubmed: 27507056
J Histochem Cytochem. 2011 Apr;59(4):391-407
pubmed: 21411810
Adv Neurobiol. 2014;8:3-20
pubmed: 25300130
Nat Med. 2007 Jan;13(1):84-8
pubmed: 17159987
Cancer Res. 2008 Oct 1;68(19):8094-103
pubmed: 18829568
Oncogene. 2015 Jul;34(28):3688-99
pubmed: 25241897
J BUON. 2010 Jul-Sep;15(3):583-91
pubmed: 20941832
Cancer Res. 2009 Nov 15;69(22):8700-9
pubmed: 19843867
Mol Cancer. 2019 Mar 18;18(1):42
pubmed: 30885232
Stem Cells Int. 2019 Jan 13;2019:3904645
pubmed: 30733805
Leukemia. 2014 Nov;28(11):2213-21
pubmed: 24705479
J Clin Invest. 2008 Jun;118(6):2111-20
pubmed: 18497886
Curr Opin Mol Ther. 2010 Dec;12(6):741-54
pubmed: 21154166
Oncotarget. 2015 Jan 1;6(1):171-84
pubmed: 25426558
Mol Ther. 2017 Jan 4;25(1):274-284
pubmed: 28129121
Mol Med Rep. 2019 Sep;20(3):2823-2831
pubmed: 31524233
Hepatology. 2013 Jun;57(6):2358-68
pubmed: 23424039
Cancer Lett. 2010 Mar 28;289(2):151-60
pubmed: 19748175
Cancer Res. 2008 Mar 1;68(5):1451-61
pubmed: 18316609
J Immunol. 2001 Dec 1;167(11):6123-31
pubmed: 11714771
Biochim Biophys Acta. 2013 Jun;1833(6):1409-20
pubmed: 23481656
Cancer Discov. 2013 Apr;3(4):388-98
pubmed: 23550147
Nat Rev Drug Discov. 2018 Jul;17(7):465-466
pubmed: 29795477
PLoS One. 2014 Aug 08;9(8):e103193
pubmed: 25105957
Stem Cells. 2012 Nov;30(11):2378-86
pubmed: 22969042
J Clin Oncol. 2006 May 1;24(13):e20-2
pubmed: 16648493
Blood. 2010 Nov 18;116(20):4099-102
pubmed: 20668228
Cancer Immunol Res. 2017 Dec;5(12):1152-1161
pubmed: 29109077
Cancers (Basel). 2019 Jan 14;11(1):
pubmed: 30646520
Eur J Immunol. 2012 Jul;42(7):1833-42
pubmed: 22585684
Leuk Lymphoma. 2015 May;56(5):1406-15
pubmed: 25248882
Adv Exp Med Biol. 2015;815:281-94
pubmed: 25427913
Clin Cancer Res. 2016 Nov 15;22(22):5592-5604
pubmed: 27267855
Clin Cancer Res. 2012 Oct 1;18(19):5314-28
pubmed: 22825584
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Glia. 2002 Sep;39(3):193-206
pubmed: 12203386
N Engl J Med. 2018 Feb 1;378(5):449-459
pubmed: 29385376
Cancer Cell Int. 2018 May 25;18:77
pubmed: 29849507
Gene Ther. 2010 Oct;17(10):1206-13
pubmed: 20555360
J Immunol. 2010 Jul 1;185(1):642-52
pubmed: 20530259
Cancer Microenviron. 2013 Aug;6(2):135-46
pubmed: 23242671
J Exp Med. 2013 Jun 3;210(6):1153-65
pubmed: 23650440
Cancer Lett. 2014 Oct 28;353(2):153-9
pubmed: 25130168
Oncoimmunology. 2015 Jun 5;4(9):e1036212
pubmed: 26405602
Clin Cancer Res. 2016 Jul 15;22(14):3571-81
pubmed: 26864211
Cell Stem Cell. 2018 Aug 02;23(2):181-192.e5
pubmed: 30082067
Cancer Res. 2010 Jan 15;70(2):697-708
pubmed: 20068175
Clin Cancer Res. 2017 Dec 1;23(23):7360-7374
pubmed: 28939749
Front Biosci. 2008 Jan 01;13:3096-100
pubmed: 17981779
J Urol. 2014 Dec;192(6):1831-41
pubmed: 24972308
Semin Cancer Biol. 2018 Oct;52(Pt 1):85-102
pubmed: 28774835
Cell Stem Cell. 2007 Oct 11;1(4):389-402
pubmed: 18371377
BMC Cancer. 2016 Jan 12;16:12
pubmed: 26758198
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6215-23
pubmed: 26512116
Lancet. 2016 Jul 30;388(10043):476-87
pubmed: 27289174
Clin Cancer Res. 2010 Jan 15;16(2):461-73
pubmed: 20068105
Blood. 2016 May 19;127(20):2406-10
pubmed: 26907630
Cell Stem Cell. 2010 Dec 3;7(6):708-17
pubmed: 21112565
Lancet. 1995 Mar 11;345(8950):615-9
pubmed: 7534855
Front Immunol. 2019 Sep 24;10:2278
pubmed: 31616440
Cancer Cell. 2008 Feb;13(2):153-66
pubmed: 18242515